ArticleScience translational medicine2023
Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis.
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Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 42 citations in OpenAlex.
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- Hedgehog/GLI Signaling at the Interface of Sterol Metabolism, Mitochondrial ROS Signaling and Cellular Plasticity.Antioxidants (Basel, Switzerland) · 2026Review
- Shared mechanisms of organ fibrosis.JCI insight · 2026Review
- Unveiling the therapeutic potential of gut microbiota metabolites for the treatment of renal fibrosis based on network pharmacology study.Bioresources and bioprocessing · 2026Article
- Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Integrated transcriptomic and metabolomic profiling reveals immune-metabolic crosstalk and predictive biomarkers of ligustrazine treatment response in idiopathic pulmonary fibrosis.Journal of translational medicine · 2026Article
- Targeting cellular senescence in diabetic kidney disease: potential of regenerative, cell-based therapies and other senotherapeutic approaches.Kidney international · 2026Review
- Macrophage β-catenin-Ihh axis induces hepatic stellate cell activation and fibrosis in metabolic dysfunction-associated steatohepatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Anti-aging effect of Hedgehog signaling.Experimental & molecular medicine · 2026Review
- Cell-cell crosstalk in kidney health and disease.Nature reviews. Nephrology · 2026Review
- Activated Hedgehog signaling in keratocytes leads to stromal stiffness and impairs corneal regeneration.NPJ Regenerative medicine · 2026Article
- Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease.Nature communications · 2025Article
- Low circulating miR-190a-5p predicts progression of chronic kidney disease.Nature communications · 2025Article
- Shared and Context-Specific Mechanisms of EMT and Cellular Plasticity in Cancer and Fibrotic Diseases.International journal of molecular sciences · 2025Review
- Fibroblast activation and heterogeneity in fibrotic disease.Nature reviews. Nephrology · 2025Review
- Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitis.Scientific reports · 2025Article
- Ovarian remodeling and aging-related chronic inflammation and fibrosis in the mammalian ovary.Journal of ovarian research · 2025Article
- Mechanism of action of IHH in ameliorating thin endometrium.The Journal of reproduction and development · 2025Article
- Kidney immunology from pathophysiology to clinical translation.Nature reviews. Immunology · 2025Review
Corrections and comments
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Authors and funding
30 authors at 10 institutions in 4 countries.
Eoin D O'SullivanCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0002-7709-6595
Katie J MylonasCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0002-7324-4597
Cuiyan XinRenal Division and Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
David P BairdCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0002-6338-3788
Cyril CarvalhoCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0001-7125-3521
Marie-Helena DochertyCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Ross CampbellCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0003-2298-9887
Kylie P MatchettCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0001-8710-7721
Scott H WaddellCancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-8696-5481
Alexander D WalkerCancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
Kevin M GallagherCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0001-5485-5336
Siyang JiaCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0009-0005-6614-3922
Steve LeungDepartment of Urology, Western General Hospital, Edinburgh EH4 2XU, UK.ORCID 0000-0002-8366-2880
Alexander LairdDepartment of Urology, Western General Hospital, Edinburgh EH4 2XU, UK.ORCID 0000-0002-7296-025X
Julia WilflingsederRenal Division and Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0230-9349
Michaela WilliLaboratory of Genetics and Physiology, NIDDK, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-2248-1998
Maximilian ReckCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Sarah FinnieCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0009-0006-6695-970X
Angela PiscoChan Zuckerberg Biohub, San Francisco, CA 94158, USA.ORCID 0000-0003-0142-2355
Sabrina Gordon-KeylockCentre for Regenerative Medicine. University of Edinburgh, Edinburgh EH16 4UU, UK.
Alexander MedvinskyCentre for Regenerative Medicine. University of Edinburgh, Edinburgh EH16 4UU, UK.
Luke BoulterCancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-7954-6705
Neil C HendersonCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0002-2273-4094
Kristina KirschnerSchool of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0001-7607-8670
Tamir ChandraCancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-7935-317X
Bryan R ConwayCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Jeremy HughesCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0002-3470-0422
Laura DenbyCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0003-1277-708X
Joseph V BonventreRenal Division and Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7144-386X
David A FerenbachCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.ORCID 0000-0002-9202-1428
Queen's Medical Centre · GBEdinburgh Cancer Research · GBBrigham and Women's Hospital · USThe Queen's Medical Research Institute · GBWestern General Hospital · GBMRC Centre for Regenerative Medicine · GBCancer Research UK Scotland Institute · GBChan Zuckerberg Initiative (United States) · USNational Institutes of Health · USRoyal Brisbane and Women's Hospital · AU
Funding
KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIRR01DK072381 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2005 to 2025
$8.6MMechanisms of Ischemic Kidney Injury and RepairR01DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPH VINCENT BONVENTRE · 1987 to 2026
$6.2MMechanisms of Ischemic Kidney Injury and RepairR37DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1993 to 2021
$5.2MKidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUH3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2019 to 2021
$3.3MKidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUG3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2017 to 2018
$2.0MBritish Heart FoundationMedical Research Council MR/N002210/1Medical Research Council MR/W000148/1Medical Research Council MR/W00089X/1NCATS NIH HHS UG3 TR002155NCATS NIH HHS UH3 TR002155NIDDK NIH HHS R01 DK039773NIDDK NIH HHS R01 DK072381NIDDK NIH HHS R37 DK039773Wellcome Trust
Abstract
Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1
Indexed as
Hedgehog ProteinsRenal Insufficiency, ChronicAnimalsFibrosisHumansInflammationMiceNF-kappa BTumor Necrosis FactorsZinc Finger Protein GLI1Hedgehog ProteinsIHH protein, humanihh protein, mouseNF-kappa BTumor Necrosis FactorsZinc Finger Protein GLI1
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.