Evidence map›Paper›PMID 37257406›Full record

ArticleNeurobiology of aging2023

Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults.

May A Beydoun, Nicole Noren Hooten, Hind A Beydoun, Jordan Weiss, Ana I Maldonado, Leslie I Katzel, Christos Davatzikos, Rao P Gullapalli, Stephen L Seliger, Guray Erus and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Computational Phenotyping of Cognitive Decline With Retest Learning.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

May A BeydounLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA. Electronic address: baydounm@mail.nih.gov.
Nicole Noren HootenLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
Hind A BeydounDepartment of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.
Jordan WeissDepartment of Demography, University of California Berkeley, Berkeley, CA, USA.
Ana I MaldonadoLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA; Department of Psychology, University of Maryland, Baltimore County, Catonsville, MD, USA.
Leslie I KatzelGeriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA; Division of Gerontology, Geriatrics and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Christos DavatzikosArtificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rao P GullapalliDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Stephen L SeligerDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Guray ErusArtificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
Shari R WaldsteinDepartment of Psychology, University of Maryland, Baltimore County, Catonsville, MD, USA; Geriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA; Division of Gerontology, Geriatrics and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · USIntel (United States) · USAlexander T. Augusta Military Medical Center · USNational Institute on Aging · USUniversity of California, Berkeley · USUniversity of Maryland, Baltimore County · US

Funding

Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)ZIAAG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$70.9M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
HANDLS Scan Substudy: Race, Socioeconomic status, and the BrainR01AG034161 · NIA · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI WALDSTEIN, SHARI · 2009 to 2013
$2.8M
Methods to Test Biomarkers of Aging as Shared Determinants of Alzheimers Disease and Related Dementias and Physical DisabilityR01AG079854 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2023 to 2025
$2.3M
Statistical Models and Mechanisms Linking Biomarkers of Aging to Cognitive-Physical Decline and DementiaRF1NS128360 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2022 to 2022
$2.2M
Epidemiology of the Inverse Comorbidity of Dementia and Cancer: Statistical Methods and Biological MechanismsR03AG070178 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2021 to 2021
$309k
Intramural NIH HHS Z99 AG999999Intramural NIH HHS ZIA AG000513NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG034161NIA NIH HHS R01 AG048069NIA NIH HHS R01 AG079854NIA NIH HHS R03 AG070178NINDS NIH HHS RF1 NS128360
6 · The paper itself

Abstract

Elevated plasma neurofilament light chain (NfL) is associated with dementia though underlying mechanisms remain unknown. We examined cross-sectional relationships of time-dependent plasma NfL with selected brain structural magnetic resonance imaging (sMRI) prognostic markers of dementia. The sample was drawn from the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study, selecting participants with complete v

Indexed as

DementiaWhite MatterBayes TheoremBiomarkersBrainFemaleHumansIntermediate FilamentsMaleMiddle AgedNeurofilament ProteinsBiomarkersNeurofilament ProteinsAgingBrain volumesHippocampusNeurofilament light chainWhite matter lesion

Identifiers

PMID37257406
PMCPMC10524231
OpenAlexW4367673685

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.