Evidence map›Paper›PMID 37258686›Full record

ReviewNature reviews. Microbiology2023

Drug delivery strategies for antibiofilm therapy.

Victor Choi, Jennifer L Rohn, Paul Stoodley, Dario Carugo, Eleanor Stride

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
24.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 156 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Victor ChoiDepartment of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK.ORCID 0000-0002-0100-8122
Jennifer L RohnDepartment of Renal Medicine, Centre for Urological Biology, Division of Medicine, University College London, London, UK.ORCID 0000-0001-8766-6056
Paul StoodleyDepartments of Microbial Infection and Immunity, Microbiology and Orthopaedics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-6069-273X
Dario CarugoNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID 0000-0002-1148-179X
Eleanor StrideDepartment of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK. eleanor.stride@eng.ox.ac.uk.ORCID 0000-0003-3371-5929
Nuffield Orthopaedic Centre · GBUniversity College London · GBUniversity of Oxford · GBUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although new antibiofilm agents have been developed to prevent and eliminate pathogenic biofilms, their widespread clinical use is hindered by poor biocompatibility and bioavailability, unspecific interactions and insufficient local concentrations. The development of innovative drug delivery strategies can facilitate penetration of antimicrobials through biofilms, promote drug dispersal and synergistic bactericidal effects, and provide novel paradigms for clinical application. In this Review, we discuss the potential benefits of such emerging techniques for improving the clinical efficacy of antibiofilm agents, as well as highlighting the existing limitations and future prospects for these therapies in the clinic.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsBiofilmsDrug Delivery SystemsAnti-Bacterial AgentsAnti-Infective Agents

Identifiers

PMID37258686
OpenAlexW4378802183

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.