Evidence map›Paper›PMID 37260849›Full record

SynthesisFrontiers in neuroscience2023

Brain function effects of exercise interventions for cognitive decline: a systematic review and meta-analysis.

Diana Karamacoska, Ali Butt, Isabella H K Leung, Ryan L Childs, Najwa-Joelle Metri, Vithya Uruthiran, Tiffany Tan, Angelo Sabag, Genevieve Z Steiner-Lim

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Diana KaramacoskaNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Ali ButtNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Isabella H K LeungNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Ryan L ChildsNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Najwa-Joelle MetriNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Vithya UruthiranSchool of Health Sciences, Western Sydney University, Campbelltown, NSW, Australia.
Tiffany TanSchool of Medicine, Western Sydney University, Penrith, NSW, Australia.
Angelo SabagNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Genevieve Z Steiner-LimNICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.
Western Sydney University · AUCamden and Campbelltown Hospitals · AUTranslational Research Institute · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Exercise is recognized as a modifiable lifestyle factor that can mitigate cognitive decline and dementia risk. While the benefits of exercise on cognitive aging have been reported on extensively, neuronal effects in adults experiencing cognitive decline have not been systematically synthesized. The aim of this systematic review was to assess the effects of exercise on cognition and brain function in people with cognitive decline associated with dementia risk. Method: A systematic search was conducted for randomized controlled trials of ≥ 4 weeks exercise (aerobic, resistance, or mind-body) that assessed cognition and brain function using neuroimaging and neurophysiological measures in people with subjective or objective cognitive decline. Study characteristics and brain function effects were narratively synthesized, while domain-specific cognitive performance was subjected to meta-analysis. Study quality was also assessed. Results: 5,204 records were identified and 12 unique trials met the eligibility criteria, representing 646 adults classified with cognitive frailty, mild or vascular cognitive impairment. Most interventions involved 40-minute sessions conducted 3 times/week. Exercise improved global cognition (g = -0.417, 95% CI, -0.694 to -0.140, Discussion: The cognitive improvements associated with exercise are likely driven by increased metabolic activity, cerebrovascular mechanisms, and neuroplasticity throughout the brain. Our paper shows the promise in, and need for, high-quality trials integrating cognitive and brain function measures to elucidate the functional relationship between exercise and brain health in populations with a high risk of dementia. Systematic review registration: PROSPERO, identifier: CRD42022291843.

Indexed as

Alzheimer's diseasecognitiondementiaexercisemild cognitive impairmentphysical activitysubjective cognitive decline

Identifiers

PMID37260849
PMCPMC10228832
OpenAlexW4376891713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.