Evidence map›Paper›PMID 37261220›Full record

ArticleBiocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al2023

Protein-mediated interactions in the dynamic regulation of acute inflammation.

Ryan Stark

Open access · diamondAbstract read
In one paragraph

Article in Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Procalcitonin and interleukin- 6 in predicting prognosis of sepsis patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ryan StarkDepartment of Pediatric Critical Care Medicine, Vanderbilt University Medical Center, 2200 Children's Way, 5121 Doctors' Office Tower, Nashville, TN 37232-9075.
Vanderbilt University Medical Center · US

Funding

Mechanisms of vascular dysfunction in acute systemic inflammationR35GM138191 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STARK, RYAN J · 2020 to 2024
$2.2M
NIGMS NIH HHS R35 GM138191
6 · The paper itself

Abstract

Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important molecules as well. These proteins are often involved in multibody complexes that work dynamically to regulate cellular health and function. Various techniques have been adapted to study these important interactions, such as affinity-based assays, mass spectrometry, and fluorescent detection. The application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory diseases. These pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation.

Indexed as

DNAInflammationProtein InteractionsRNASepsisTherapeutics

Identifiers

PMID37261220
PMCPMC10231872
OpenAlexW4378952853

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.