ArticleNature communications2023
Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD
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In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
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Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- Modulation of miR-23b Wnt/β-catenin Axis Strengthens Endothelial Barrier Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.Cell reports · 2026Article
- Systematic Design and Evaluation of Nasal Drug Delivery for Central Nervous System Disease from Experimental to Clinical Application.Pharmaceutics · 2026Review
- A dual-pathway Wnt-IL-13 fusion protein enhances human intestinal regeneration through tuft cell activation.The Journal of biological chemistry · 2026Article
- Peptide RL-QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β-Catenin Axis.Exploration (Beijing, China) · 2026Article
- An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male mice.EBioMedicine · 2026Article
- Targeting frizzled receptors (FZDs) for anti-tumor therapy: From orthosteric to allosteric inhibition.Acta pharmaceutica Sinica. B · 2026Review
- Spatial Transcriptomics and Dual Dye Mapping Identify Wnt-Driven BBB Protection in Endothelial EphA4-Deficiency.Research square · 2026Article
- KIF11 prevents retinal endothelial ferroptosis in familial exudative vitreoretinopathy by inhibiting phosphorylation-driven PRDX1 phase separation.Nature communications · 2026Article
- A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling.bioRxiv : the preprint server for biology · 2026Article
- Nitrogen-Boosted HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microglial Fkbp5 Impairs Post-Stroke Vascular Integrity and Regeneration by Promoting Yap1-Mediated Glycolysis and Oxidative Phosphorylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Development of the blood-brain barrier.Development (Cambridge, England) · 2026Review
- Pharmacological interventions targeting the gut-brain axis in neurological disorders: mechanisms and translational applications.Frontiers in neuroscience · 2026Review
- When Mitochondria Falter, the Barrier Fails: Mechanisms of Inner Blood-Retinal Barrier (iBRB) Injury and Opportunities for Mitochondria-Targeted Repair.International journal of molecular sciences · 2025Review
- C1q limits cystoid edema by maintaining basal β-catenin-dependent signaling and blood-retina barrier function.JCI insight · 2025Article
- Blood‑brain barrier dysfunction in schizophrenia: Mechanisms and implications (Review).International journal of molecular medicine · 2025Review
- Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke.Nature cardiovascular research · 2025Article
- Article
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 1 country.
Jie DingDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Sung-Jin LeeSurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.
Lukas VlahosDepartment of Systems Biology, Columbia University, Columbia, NY, 10032, USA.
Kanako YukiDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Cara C RadaDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Vincent van UnenDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID 0000-0001-9339-8430
Meghah VuppalapatySurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.
Hui ChenSurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.
Asmiti SuraSurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.
Aaron K McCormickDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Madeline TomaskeDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Samira AlwahabiDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Huy NguyenSurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.
William NowatzkeSurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.
Lily KimDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Lisa KellyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Douglas VollrathDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Andrea CalifanoDepartment of Systems Biology, Columbia University, Columbia, NY, 10032, USA.
Wen-Chen YehSurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.ORCID 0000-0002-8837-8301
Yang LiSurrozen, Inc. South San Francisco, South San Francisco, CA, 94080, USA.ORCID 0000-0002-7134-5685
Calvin J KuoDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, 94305, USA. cjkuo@stanford.edu.ORCID 0000-0002-7427-5985
Stanford University · USColumbia University · USStanford Medicine · US
Funding
Predicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell LevelR35CA197745 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDREA CALIFANO · 2015 to 2026
$11.5MRegulation of actively proliferating and quiescent intestinal stem cellsU01DK085527 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2009 to 2023
$6.9MStructure-based Bioengineering of Wnt Surrogates for Intestinal Stem Cell Biology and TherapyR01DK115728 · NIDDK · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER, KUO, CALVIN J · 2018 to 2022
$3.9MRegulation of Blood-Brain Barrier Function by the RECK/GPR124/Wnt7 PathwayR01NS100904 · NINDS · STANFORD UNIVERSITY · PI CALVIN J KUO · 2017 to 2026
$3.6MProgram in Translational and Experimental HematologyT32HL120824 · NHLBI · STANFORD UNIVERSITY · PI MAJETI, RAVINDRA · 2014 to 2023
$2.4MRPE Energy Metabolism and Cell PhenotypeR01EY025790 · NEI · STANFORD UNIVERSITY · PI VOLLRATH, DOUGLAS E. · 2016 to 2021
$2.4MAnimal Research Equipment, Digital Cages & Metabolic, Avoidance, Fear Conditioning, Place Preference, Self-Administration, Open Field, & Microdialysis Systems for Translational NeuroscienceS10OD030452 · OD · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2021 to 2021
$743kNCI NIH HHS R35 CA197745NEI NIH HHS R01 EY025790NHLBI NIH HHS T32 HL120824NIDDK NIH HHS R01 DK115728NIDDK NIH HHS U01 DK085527NIH HHS S10 OD030452NINDS NIH HHS R01 NS100904
Abstract
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD
Indexed as
Blood-Brain BarrierFrizzled ReceptorsAnimalsBlood-Retinal BarrierMiceRetinaWnt Signaling PathwayFrizzled Receptors
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.