Evidence map›Paper›PMID 37269361›Full record

ArticleMolecular genetics and genomics : MGG2023

The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours.

Chiemi F Lynch-Sutherland, Lorissa I McDougall, Peter A Stockwell, Suzan N Almomani, Robert J Weeks, Jackie L Ludgate, Teena K J B Gamage, Aniruddha Chatterjee, Joanna L James, Michael R Eccles and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Chiemi F Lynch-SutherlandDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand. clynch-sutherland@cmri.org.au.ORCID http://orcid.org/0000-0002-0395-1878
Lorissa I McDougallDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
Peter A StockwellDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
Suzan N AlmomaniDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
Robert J WeeksDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
Jackie L LudgateDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
Teena K J B GamageDepartment of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Aniruddha ChatterjeeDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
Joanna L JamesDepartment of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Michael R EcclesDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
Erin C MacaulayDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.
University of Otago · NZMaurice Wilkins Centre · NZUniversity of Auckland · NZDunedin Public Hospital · NZ

Funding

Marsden Fund 16-UOO-178
6 · The paper itself

Abstract

Transposable elements (TEs) are genetic elements that have evolved as crucial regulators of human development and cancer, functioning as both genes and regulatory elements. When TEs become dysregulated in cancer cells, they can serve as alternate promoters to activate oncogenes, a process known as onco-exaptation. This study aimed to explore the expression and epigenetic regulation of onco-exaptation events in early human developmental tissues. We discovered co-expression of some TEs and oncogenes in human embryonic stem cells and first trimester and term placental tissues. Previous studies identified onco-exaptation events in various cancer types, including an AluJb SINE element-LIN28B interaction in lung cancer cells, and showed that the TE-derived LIN28B transcript is associated with poor patient prognosis in hepatocellular carcinoma. This study further characterized the AluJb-LIN28B transcript and confirmed that its expression is restricted to the placenta. Targeted DNA methylation analysis revealed differential methylation of the two LIN28B promoters between placenta and healthy somatic tissues, indicating that some TE-oncogene interactions are not cancer-specific but arise from the epigenetic reactivation of developmental TE-derived regulatory events. In conclusion, our findings provide evidence that some TE-oncogene interactions are not limited to cancer and may originate from the epigenetic reactivation of TE-derived regulatory events that are involved in early development. These insights broaden our understanding of the role of TEs in gene regulation and suggest the potential importance of targeting TEs in cancer therapy beyond their conventional use as cancer-specific markers.

Indexed as

DNA Transposable ElementsNeoplasmsEpigenesis, GeneticFemaleHumansPlacentaPregnancyRegulatory Sequences, Nucleic AcidRNA-Binding ProteinsDNA Transposable ElementsLIN28B protein, humanRNA-Binding ProteinsLIN28BOnco-exaptationPlacental DevelopmentTransposable Elements (TEs)

Identifiers

PMID37269361
PMCPMC10363060
OpenAlexW4379259316

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.