Evidence map›Paper›PMID 37274281›Full record

ReviewFrontiers in oncology2023

Computational approaches for drug repurposing in oncology: untapped opportunity for high value innovation.

Shraddha M Dalwadi, Andrew Hunt, Mark D Bonnen, Yohannes T Ghebre

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shraddha M DalwadiDepartment of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Andrew HuntDepartment of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Mark D BonnenDepartment of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Yohannes T GhebreDepartment of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
The University of Texas Health Science Center at San Antonio · US

Funding

Repurposing esomeprazole for the treatment of sclerodermaR01AR077445 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Yohannes T Ghebre · 2022 to 2026
$2.1M
Combination of PPI and pirfenidone to enhance antifibrotic efficacyR01HL137703 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GHEBRE, YOHANNES T · 2017 to 2021
$2.0M
Repurposing esomeprazole for the treatment of sclerodermaR56AR077445 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI GHEBRE, YOHANNES T · 2020 to 2020
$352k
NHLBI NIH HHS R01 HL137703NIAMS NIH HHS R01 AR077445NIAMS NIH HHS R56 AR077445
6 · The paper itself

Abstract

Historically, the effort by academia and industry to develop new chemical entities into lifesaving drugs has limited success in meeting the demands of today's healthcare. Repurposing drugs that are originally approved by the United States Food and Drug Administration or by regulatory authorities around the globe is an attractive strategy to rapidly develop much-needed therapeutics for oncologic indications that extend from treating cancer to managing treatment-related complications. This review discusses computational approaches to harness existing drugs for new therapeutic use in oncology.

Indexed as

clinical trialsdrug repurposinginformaticsoncologypharmacology

Identifiers

PMID37274281
PMCPMC10233043
OpenAlexW4377023296

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.