Evidence map›Paper›PMID 37275441›Full record

ArticleFrontiers in ophthalmology2023

MURIN: Multimodal Retinal Imaging and Navigated-laser-delivery for dynamic and longitudinal tracking of photodamage in murine models.

Jose J Rico-Jimenez, Joel Jovanovic, Stephanie L Nolen, Joseph D Malone, Gopikrishna Rao, Edward M Levine, Yuankai K Tao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jose J Rico-JimenezVanderbilt University, Dept. of Biomedical Engineering, Nashville, TN 37208, USA.
Joel JovanovicVanderbilt University Medical Center, Vanderbilt Eye Institute, Nashville, TN 37208, USA.
Stephanie L NolenVanderbilt University, Dept. of Biomedical Engineering, Nashville, TN 37208, USA.
Joseph D MaloneVanderbilt University, Dept. of Biomedical Engineering, Nashville, TN 37208, USA.
Gopikrishna RaoVanderbilt University, Dept. of Biomedical Engineering, Nashville, TN 37208, USA.
Edward M LevineVanderbilt University Medical Center, Vanderbilt Eye Institute, Nashville, TN 37208, USA.
Yuankai K TaoVanderbilt University, Dept. of Biomedical Engineering, Nashville, TN 37208, USA.

Funding

Novel Activators of Regeneration in Muller gliaU01EY027265 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVINE, EDWARD M, PATTON, JAMES G. · 2016 to 2018
$2.2M
Intraoperative Optical Coherence Tomography for Ophthalmic Surgical GuidanceR01EY030490 · NEI · VANDERBILT UNIVERSITY · PI TAO, YUANKAI KENNY · 2019 to 2023
$1.8M
Intraoperative imaging of macular hole repair to predict visual function outcomesR01EY031769 · NEI · VANDERBILT UNIVERSITY · PI TAO, YUANKAI KENNY · 2020 to 2023
$1.4M
Neurogenic potential of murine Müller glia following retinal injury and conditional inactivation of p27Kip1R21EY033473 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVINE, EDWARD M · 2022 to 2023
$476k
Regulation of the lens transcriptome and chromatin architecture by FOXE3R21EY033471 · NEI · MIAMI UNIVERSITY OXFORD · PI ROBINSON, MICHAEL L · 2022 to 2023
$397k
NEI NIH HHS R01 EY030490NEI NIH HHS R01 EY031769NEI NIH HHS R21 EY033471NEI NIH HHS R21 EY033473NEI NIH HHS U01 EY027265
6 · The paper itself

Abstract

Laser-induced photodamage is a robust method for investigating retinal pathologies in small animals. However, aiming of the photocoagulation laser is often limited by manual alignment and lacks real-time feedback on lesion location and severity. Here, we demonstrate a multimodality OCT and SLO ophthalmic imaging system with an image-guided scanning laser lesioning module optimized for the murine retina. The proposed system enables targeting of focal and extended area lesions under OCT guidance to benefit visualization of photodamage response and the precision and repeatability of laser lesion models of retinal injury.

Indexed as

fluorescenceophthalmic imagingoptical coherence tomographyphotodamagescanning laser ophthalmoscopy

Identifiers

PMID37275441
PMCPMC10238074

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.