Evidence map›Paper›PMID 37277605›Full record

ArticlePediatric research2023

Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage.

Tala El Tal, Marie-Paule Morin, Shaun K Morris, Daniel S Farrar, Roberta A Berard, Fatima Kakkar, Charlotte Moore Hepburn, Krista Baerg, Camille Beaufils, Terri-Lyn Bennett and 35 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 20 institutions in 1 country.

Tala El Tal *Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Marie-Paule Morin *Division of Paediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
Shaun K Morris *Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. shaun.morris@sickkids.ca.
Daniel S FarrarCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada.
Roberta A BerardDivision of Rheumatology, Department of Pediatrics, London Health Sciences Centre, London, ON, Canada.
Fatima KakkarDivision of Infectious Diseases, CHU Sainte-Justine, Montreal, QC, Canada.
Charlotte Moore HepburnDepartment of Pediatrics, Division of Paediatric Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Krista BaergDepartment of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada.
Camille BeaufilsDivision of Paediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
Terri-Lyn BennettPublic Health Agency of Canada, Ottawa, ON, Canada.
Susanne M BenselerAlberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Guillaume Beaudoin-BussièresDepartment of Microbiology, Immunology and Infectious Diseases, Université de Montréal, Montreal, QC, Canada.
Kevin ChanDepartment of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Claude CyrService de Soins Intensifs Pédiatriques, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Nagib DahdahDivision of Pediatric Cardiology, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
Elizabeth J DonnerDivision of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Olivier DrouinDivision of General Pediatrics, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
Rojiemiahd EdjocPublic Health Agency of Canada, Ottawa, ON, Canada.
Maryem EljaouhariPublic Health Agency of Canada, Ottawa, ON, Canada.
Joanne E EmbreeDepartment of Paediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Catherine FarrellDivision of Paediatric Intensive Care, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
Andrés FinziDepartment of Microbiology, Immunology and Infectious Diseases, Université de Montréal, Montreal, QC, Canada.
Sarah ForgieDivision of Infectious Diseases, Department of Pediatrics, University of Alberta and Stollery Children's Hospital, Edmonton, AB, Canada.
Ryan GirouxWomen's and Children's Health Program, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
Kristopher T KangDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Melanie KingCanadian Paediatric Surveillance Program, Canadian Paediatric Society, Ottawa, ON, Canada.
Melanie Laffin ThibodeauCanadian Paediatric Surveillance Program, Canadian Paediatric Society, Ottawa, ON, Canada.
Bianca LangDivision of Rheumatology, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Ronald M LaxerDivision of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Thuy Mai LuuDivision of General Pediatrics, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
Brian W McCrindleThe Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Julia OrkinDepartment of Pediatrics, Division of Paediatric Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Jesse PapenburgDivision of Pediatric Infectious Diseases, Department of Pediatrics, Montreal Children's Hospital, Montreal, QC, Canada.
Catherine M PoundDivision of Consulting Pediatrics, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Victoria E PriceDivision of Paediatric Hematology/Oncology, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Jean-Philippe Proulx-GauthierDepartment of Pediatrics, CHU de Québec-Université Laval, Quebec City, QC, Canada.
Rupeena PurewalDepartment of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada.
Manish SadaranganiDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Marina I SalvadoriPublic Health Agency of Canada, Ottawa, ON, Canada.
Roseline ThibeaultDivision of Pediatric Infectious Diseases, Department of Paediatrics, CHU de Quebec-University of Laval, Quebec City, QC, Canada.
Karina A TopDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Isabelle Viel-ThériaultDivision of Infectious Diseases, Department of Pediatrics, CHU de Québec-Université Laval, Quebec City, QC, Canada.
Elie HaddadDivision of Paediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada. elie.haddad@umontreal.ca.
Rosie ScuccimarriDivision of Paediatric Rheumatology, Montreal Children's Hospital/McGill University Health Centre, Montreal, QC, Canada.
Rae S M YeungDivision of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. rae.yeung@sickkids.ca.
Centre Hospitalier Universitaire Sainte-Justine · CAHospital for Sick Children · CAUniversité de Montréal · CAPublic Health Agency of Canada · CADalhousie University · CAUniversity of Toronto · CACanadian Paediatric Society · CAMcGill University Health Centre · CASickKids Foundation · CAUniversité Laval · CAUniversity of Saskatchewan · CABC Children's Hospital · CACentre Hospitalier Universitaire de Sherbrooke · CAChildren's Hospital of Eastern Ontario · CALondon Health Sciences Centre · CAUnity Health TorontoUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPaediatric inflammatory multisystem syndrome (PIMS) is a rare condition temporally associated with SARS-CoV-2 infection. Using national surveillance data, we compare presenting features and outcomes among children hospitalized with PIMS by SARS-CoV-2 linkage, and identify risk factors for intensive care (ICU).

methodsCases were reported to the Canadian Paediatric Surveillance Program by a network of >2800 pediatricians between March 2020 and May 2021. Patients with positive versus negative SARS-CoV-2 linkages were compared, with positive linkage defined as any positive molecular or serologic test or close contact with confirmed COVID-19. ICU risk factors were identified with multivariable modified Poisson regression.

resultsWe identified 406 children hospitalized with PIMS, including 49.8% with positive SARS-CoV-2 linkages, 26.1% with negative linkages, and 24.1% with unknown linkages. The median age was 5.4 years (IQR 2.5-9.8), 60% were male, and 83% had no comorbidities. Compared to cases with negative linkages, children with positive linkages experienced more cardiac involvement (58.8% vs. 37.4%; p < 0.001), gastrointestinal symptoms (88.6% vs. 63.2%; p < 0.001), and shock (60.9% vs. 16.0%; p < 0.001). Children aged ≥6 years and those with positive linkages were more likely to require ICU.

conclusionsAlthough rare, 30% of PIMS hospitalizations required ICU or respiratory/hemodynamic support, particularly those with positive SARS-CoV-2 linkages. IMPACT: We describe 406 children hospitalized with paediatric inflammatory multisystem syndrome (PIMS) using nationwide surveillance data, the largest study of PIMS in Canada to date. Our surveillance case definition of PIMS did not require a history of SARS-CoV-2 exposure, and we therefore describe associations of SARS-CoV-2 linkages on clinical features and outcomes of children with PIMS. Children with positive SARS-CoV-2 linkages were older, had more gastrointestinal and cardiac involvement, and hyperinflammatory laboratory picture. Although PIMS is rare, one-third required admission to intensive care, with the greatest risk amongst those aged ≥6 years and those with a SARS-CoV-2 linkage.

Indexed as

COVID-19SARS-CoV-2CanadaChildChild, PreschoolFemaleHumansMaleSystemic Inflammatory Response Syndrome

Identifiers

PMID37277605
PMCPMC10241135
OpenAlexW4379382746

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.