ArticleScientific reports2023
In-vitro and in-silico evidence for oxidative stress as drivers for RDW.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- The incremental prognostic effect of red blood cell distribution width in 28-day mortality among critically ill patients with HFpEF.American heart journal plus : cardiology research and practice · 2026Article
- Red blood cell distribution width-to-albumin ratio as a novel predictor for mortality in breast cancer patients admitted to ICU: a retrospective analysis using MIMIC-IV 3.1.BMC medical informatics and decision making · 2026Article
- Age-Associated Variations in Complete Blood Cell Count Parameters and Derived Indices Among Community-Dwelling Chinese Older Adults.Journal of clinical laboratory analysis · 2026Article
- Elevated red cell distribution width as a prognostic indicator in critically ill patients with atrial fibrillation and chronic kidney disease.BMC cardiovascular disorders · 2026Article
- Long-term exposure to polystyrene microplastics exacerbates seizure symptoms via lipid metabolic disruption and ferroptosis: insights from multi-omics analyses.Journal of nanobiotechnology · 2026Article
- Association between hemoglobin-to-red blood cell distribution width ratio trajectory patterns and in-hospital mortality in critically ill patients with cirrhosis: a retrospective cohort study based on MIMIC-IV and eICU-CRD.BMC medical informatics and decision making · 2026Article
- Machine learning-based precision subtyping and risk prediction in sepsis: a retrospective analysis using MIMIC-IV database.BMC infectious diseases · 2026Article
- A New and Robust Prognostic Biomarker for Mortality Risk Prediction in Dialysis Patients With Coronary Artery Disease: Red Cell Distribution Width-to-Albumin Ratio.Reviews in cardiovascular medicine · 2026Article
- Elevated Red Blood Cell Distribution Width Predicts Mortality and Major Adverse Cardiovascular Events After Acute Myocardial Infarction: A Large Propensity Score-Matched Cohort Study.Journal of clinical medicine · 2026Article
- The role of red blood cell distribution width in prognosis prediction among critically ill patients with obstructive sleep apnea: Insights from the MIMIC-IV database.Scientific reports · 2026Article
- Longitudinal metabolomics study of phosphate-adenine-guanosine-glucose-saline-mannitol stored red blood cells.Transfusion · 2026Article
- The prognostic value of red cell distribution width-to-albumin ratio (RAR) in COVID-19 pneumonia: implications for early diagnosis.Virology journal · 2026Article
- Predictive value of hemoglobin-to-red cell distribution width ratio for mortality in new-onset atrial fibrillation after cardiac surgery a machine learning study based on the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Association Between Red Cell Distribution Width-Coefficient of Variation (RDW-CV) and Bacterial Vaginosis: A Cross-Sectional Study and External Validation.International journal of women's health · 2026Article
- Relationship between persistent atrial fibrillation in high-altitude regions and left atrial diameter, red cell distribution width, and NT-ProBNP: a retrospective case-control study.Frontiers in cardiovascular medicine · 2026Article
- Allostatic load in thyroid cancer is higher than that of other cancers: A secondary analysis using NHANES.PloS one · 2026Article
- Early Clinical, Laboratory, and Imaging Correlates of Neurological Dysfunction in Adults Presenting to the Emergency Department with Sepsis: A Single-Center Retrospective Study.Juntendo medical journal · 2026Article
- Red Cell Distribution Width Predicts Mortality in Critically Ill Patients with COPD and Atrial Fibrillation: A Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Red Blood Cell Distribution Width-to-Albumin Ratio (RAR) Is an Independent Predictor of Mortality in Non-Anemic Elderly with Hip Fractures.International journal of general medicine · 2026Article
- RAR and infant mortality: a crucial link in cardiac surgery outcomes.Frontiers in immunology · 2026Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Red blood cell distribution width (RDW) is a biomarker associated with a variety of clinical outcomes. While anemia and subclinical inflammation have been posed as underlying pathophysiology, it is unclear what mechanisms underlie these assocations. Hence, we aimed to unravel the mechanisms in silico using a large clinical dataset and validate our findings in vitro. We retrieved complete blood counts (CBC) from 1,403,663 measurements from the Utrecht Patient Oriented Database, to model RDW using gradient boosting regression. We performed (sex-stratified) analyses in patients with anemia, patients younger/older than 50 and validation across platforms and care settings. We then validated our hypothesis regarding oxidative stress using an in vitro approach. Only percentage microcytic (pMIC) and macrocytic (pMAC) erythrocytes and mean corpuscular volume were most important in modelling RDW (RMSE = 0.40, R
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