Evidence map›Paper›PMID 37288530›Full record

Trial reportPsychological medicine2024

A core component of psychological therapy causes adaptive changes in computational learning mechanisms.

Quentin Dercon, Sara Z Mehrhof, Timothy R Sandhu, Caitlin Hitchcock, Rebecca P Lawson, Diego A Pizzagalli, Tim Dalgleish, Camilla L Nord

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychological medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Reduced Pavlovian Value Updating Alters Decision-Making in Sign-Trackers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Article
  6. The challenge of learning adaptive mental behavior.Journal of psychopathology and clinical science · 2024
    Article
  7. Article
  8. Review
  9. Micro-narratives: A Scalable Method for Eliciting Stories of People's Lived Experience.Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Quentin DerconMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8264-347X
Sara Z MehrhofMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8267-3898
Timothy R SandhuMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7127-0142
Caitlin HitchcockMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2435-0713
Rebecca P LawsonMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1228-1244
Diego A PizzagalliDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7772-1143
Tim DalgleishMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7304-2231
Camilla L NordMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9281-3417

Funding

Medical Research Council MC_UU_00030/12Medical Research Council MC_UU_00030/5Wellcome TrustWellcome Trust 206691
6 · The paper itself

Abstract

backgroundCognitive distancing is an emotion regulation strategy commonly used in psychological treatment of various mental health disorders, but its therapeutic mechanisms are unknown.

methods935 participants completed an online reinforcement learning task involving choices between pairs of symbols with differing reward contingencies. Half (49.1%) of the sample was randomised to a cognitive self-distancing intervention and were trained to regulate or 'take a step back' from their emotional response to feedback throughout. Established computational (

resultsCognitive distancing improved task performance, including when participants were later tested on novel combinations of symbols without feedback. Group differences in computational model-derived parameters revealed that cognitive distancing resulted in clearer representations of option values (estimated 0.17 higher inverse temperatures). Simultaneously, distancing caused increased sensitivity to negative feedback (estimated 19% higher loss learning rates). Exploratory analyses suggested this resulted from an evolving shift in strategy by distanced participants: initially, choices were more determined by expected value differences between symbols, but as the task progressed, they became more sensitive to negative feedback, with evidence for a difference strongest by the end of training.

conclusionsAdaptive effects on the computations that underlie learning from reward and loss may explain the therapeutic benefits of cognitive distancing. Over time and with practice, cognitive distancing may improve symptoms of mental health disorders by promoting more effective engagement with negative information.

Indexed as

Reinforcement, PsychologyRewardHumansTask Performance and AnalysisComputational psychiatrydistancingemotion regulationpsychotherapyreinforcement learning

Identifiers

PMID37288530
PMCPMC11949617

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.