Evidence map›Paper›PMID 37292102›Full record

ArticleHealth science reports2023

Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case-control study in the Upper West Region, Ghana.

Peter K Selleh, Enoch O Anto, Wina I O Boadu, Benedict Sackey, Lilian A Boateng, Charles Nkansah, Frederick Nsafoah, Abdul R Saasi, Selina Mintaah, Yaw A Wiafe and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health science reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Peter K SellehDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Enoch O AntoDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0001-9023-6612
Wina I O BoaduDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0002-2660-1707
Benedict SackeyDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Lilian A BoatengDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Charles NkansahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0001-6986-9976
Frederick NsafoahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Abdul R SaasiDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Selina MintaahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Yaw A WiafeDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Charles DerigubahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Emmanuel E KorsahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Joseph FrimpongDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0002-9128-7208
Ezekiel AnsahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Valentine C K T TamakloeDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0002-2411-6441
Patrick AduDepartment of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana.
Joseph BoachieDepartment of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana.
Otchere Addai-MensahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0001-9225-5876
Kwame Nkrumah University of Science and Technology · GHUniversity of Cape Coast · GHEdith Cowan University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Type 2 diabetes mellitus (T2DM) individuals are at a higher risk of developing diabetes complications, with approximately 80% complication-related mortality. The increased morbidity and mortality among T2DM patients are partly due to dysregulated hemostasis. This study determined the quality of glycemic control in T2DM and its association with markers of coagulation and inhibitors of fibrinolysis. Methods: This case-control study recruited 90 participants involving: 30 T2DM patients with good glycemic control, 30 with poor glycemic control, and 30 nondiabetic subjects as controls at a Municipal Hospital in Ghana. Fasting blood glucose, glycated hemoglobin, activated partial thromboplastin time (APTT), prothrombin time (PT), calculated international normalized ratio (INR), and full blood count (FBC) were determined for each respondent. Plasma levels of plasminogen activator inhibitor-1 (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI) were determined using the solid-phase sandwich enzyme-linked immunosorbent assay method. Data were analyzed using R language software. Results: Plasma PAI-1 antigen levels were significantly higher in the participants with poor glycemic control as compared to participants with good glycemic control ( Conclusion: PAI-1 levels were significantly increased in T2DM with poor glycemic control and emerged as the best predictor for poor glycemic control. Good glycemic management to control the plasma levels of PAI-1 is required to prevent hypercoagulability and thrombotic disorders.

Indexed as

coagulationglycemic controlplasminogen activator inhibitorthrombin activatable fibrinolysis inhibitortype 2 diabetes mellitus

Identifiers

PMID37292102
PMCPMC10246457
OpenAlexW4379967701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.