Evidence map›Paper›PMID 37292966›Full record

ArticlebioRxiv : the preprint server for biology2023

A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.

Panagiotis Oikonomou, Helena C Cirne, Nandan L Nerurkar

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Panagiotis OikonomouDepartment of Biomedical Engineering, Columbia University, New York NY 10027.
Helena C CirneDepartment of Biomedical Engineering, Columbia University, New York NY 10027.
Nandan L NerurkarDepartment of Biomedical Engineering, Columbia University, New York NY 10027.
Columbia University · US

Funding

The Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2M
Investigation of a neuromesendodermal progenitor population in the posterior avian endodermR35GM142995 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NERURKAR, NANDAN L · 2021 to 2025
$2.2M
NIDDK NIH HHS P30 DK132710NIGMS NIH HHS R35 GM142995
6 · The paper itself

Abstract

While mechanical and biochemical descriptions of development are each essential, integration of upstream morphogenic cues with downstream tissue mechanics remains understudied in many contexts during vertebrate morphogenesis. A posterior gradient of Fibroblast Growth Factor (FGF) ligands generates a contractile force gradient in the definitive endoderm, driving collective cell movements to form the hindgut. Here, we developed a two-dimensional chemo-mechanical model to investigate how mechanical properties of the endoderm and transport properties of FGF coordinately regulate this process. We began by formulating a 2-D reaction-diffusion-advection model that describes the formation of an FGF protein gradient due to posterior displacement of cells transcribing unstable

Indexed as

chemo-mechanical modelchickendodermhindgutmorphogenesis

Identifiers

PMID37292966
PMCPMC10245718
OpenAlexW4377097401

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.