Evidence map›Paper›PMID 37293082›Full record

ArticlebioRxiv : the preprint server for biology2023

PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages.

Amit Kumar Subudhi, Judith L Green, Rohit Satyam, Todd Lenz, Rahul P Salunke, Muhammad Shuaib, Ioannis Isaioglou, Steven Abel, Mohit Gupta, Luke Esau and 18 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 8 institutions in 5 countries.

Amit Kumar SubudhiPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Judith L GreenMalaria Parasitology Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
Rohit SatyamDepartment of Computer Science, Jamia Millia Islamia, Jamia Nagar, Okhla, New Delhi, Delhi 110025, India.
Todd LenzDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California, United States of America.
Rahul P SalunkePathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Muhammad ShuaibPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Ioannis IsaioglouCell Migration and Signaling Laboratory, Bioscience Program, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Steven AbelDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California, United States of America.
Mohit GuptaDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California, United States of America.
Luke EsauKAUST Core Labs, KAUST, Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Tobias MourierPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Raushan NugmanovaPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Sara MfarrejPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Rupali SivapurkarPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Zenaida SteadPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Fathia Ben RachedPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Yogesh OtswalLaboratory of Chromatin Biochemistry, Bioscience Program, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Rachid SougratKAUST Core Labs, KAUST, Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Ashraf DadaDepartment of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia.
Abdullah Fuaad KadamanyDepartment of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia.
Wolfgang FischleLaboratory of Chromatin Biochemistry, Bioscience Program, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Jasmeen MerzabanCell Migration and Signaling Laboratory, Bioscience Program, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Ellen KnuepferMalaria Parasitology Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
David J P FergusonNuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Oxford OX1 2JD, United Kingdom.
Ishaan GuptaDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi, India.
Karine G Le RochDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California, United States of America.
Anthony A HolderMalaria Parasitology Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
Arnab PainPathogen Genomics Group, Bioscience Program, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
King Abdullah University of Science and Technology · SAUniversity of California, Riverside · USThe Francis Crick Institute · GBKing Faisal Specialist Hospital & Research Centre · SAHokkaido University · JPIndian Institute of Technology Delhi · INJamia Millia Islamia · INOxford Brookes University · GB

Funding

Chromatin structure and control of gene expression in the human malaria parasiteR01AI136511 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$3.4M
Evolution of the 3D chromatin structure in apicomplexan parasitesR21AI142506 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2019 to 2020
$479k
NIAID NIH HHS R01 AI136511NIAID NIH HHS R21 AI142506Wellcome Trust
6 · The paper itself

Abstract

Malaria pathogenicity results from the parasite's ability to invade, multiply within and then egress from the host red blood cell (RBC). Infected RBCs are remodeled, expressing antigenic variant proteins (such as PfEMP1, coded by the

Identifiers

PMID37293082
PMCPMC10245809
OpenAlexW4377968265

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.