Evidence map›Paper›PMID 37294081›Full record

ArticleeLife2023

Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population.

Khai C Ang, Victor A Canfield, Tiffany C Foster, Thaddeus D Harbaugh, Kathryn A Early, Rachel L Harter, Katherine P Reid, Shou Ling Leong, Yuka Kawasawa, Dajiang Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Khai C AngDepartment of Pathology, Penn State College of Medicine, Hershey, United States.ORCID https://orcid.org/0000-0001-7695-9953
Victor A CanfieldDepartment of Pathology, Penn State College of Medicine, Hershey, United States.
Tiffany C FosterDepartment of Pathology, Penn State College of Medicine, Hershey, United States.
Thaddeus D HarbaughDepartment of Pathology, Penn State College of Medicine, Hershey, United States.
Kathryn A EarlyDepartment of Pathology, Penn State College of Medicine, Hershey, United States.
Rachel L HarterDepartment of Pathology, Penn State College of Medicine, Hershey, United States.
Katherine P ReidDepartment of Pathology, Penn State College of Medicine, Hershey, United States.
Shou Ling LeongDepartment of Family & Community Medicine, Penn State College of Medicine, Hershey, United States.
Yuka KawasawaDepartment of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, United States.ORCID https://orcid.org/0000-0002-8638-6738
Dajiang LiuDepartment of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, United States.
John W HawleySalybia Mission Project, Saint David Parish, Dominica.
Keith C ChengDepartment of Pathology, Penn State College of Medicine, Hershey, United States.ORCID https://orcid.org/0000-0002-5350-5825
Pennsylvania State University · US

Funding

Function of calcium exchangers in vetebrate pigmentationR01AR052535 · NIAMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHENG, KEITH CHI · 2006 to 2010
$1.7M
NIAMS NIH HHS R01 AR052535
6 · The paper itself

Abstract

Our interest in the genetic basis of skin color variation between populations led us to seek a Native American population with genetically African admixture but low frequency of European light skin alleles. Analysis of 458 genomes from individuals residing in the Kalinago Territory of the Commonwealth of Dominica showed approximately 55% Native American, 32% African, and 12% European genetic ancestry, the highest Native American genetic ancestry among Caribbean populations to date. Skin pigmentation ranged from 20 to 80 melanin units, averaging 46. Three albino individuals were determined to be homozygous for a causative multi-nucleotide polymorphism

Indexed as

American Indian or Alaska NativeCaribbean PeopleMelaninsSkin PigmentationAllelesAntigens, NeoplasmAntiportersBlack PeopleEthnicityHumansMembrane Transport ProteinsPolymorphism, Single NucleotideWhite PeopleAntigens, NeoplasmAntiportersMelaninsMembrane Transport ProteinsOCA2 protein, humanSLC24A5 protein, humanSLC45A2 protein, humanadmixturealbinismevolutionary biologygeneticshumanNative Americanpigmentationpopulation genetics

Identifiers

PMID37294081
PMCPMC10371226
OpenAlexW4379966588

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.