Evidence map›Paper›PMID 37298339›Full record

ArticleInternational journal of molecular sciences2023

GC-MS/MS Determination of Synthetic Cathinones: 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study.

Melani Nuñez-Montero, Claudia Lombroni, Nunzia La Maida, Maria Concetta Rotolo, Simona Pichini, Esther Papaseit, Olga Hladun, Mireia Ventura, Lourdes Poyatos, Clara Pérez-Mañá and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Melani Nuñez-MonteroDepartment of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.
Claudia LombroniNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.
Nunzia La MaidaNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-0127-4225
Maria Concetta RotoloNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.
Simona PichiniNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.
Esther PapaseitDepartment of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.
Olga HladunDepartment of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.
Mireia VenturaEnergy Control, Associació Benestar i Desenvolupament, 08012 Barcelona, Spain.
Lourdes PoyatosDepartment of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.ORCID 0000-0002-4641-8600
Clara Pérez-MañáDepartment of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.ORCID 0000-0001-6343-6918
Magí FarréDepartment of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.ORCID 0000-0001-8338-7543
Emilia MarcheiNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-7158-6032
Universitat Autònoma de Barcelona · ESIstituto Superiore di Sanità · IT

Funding

Instituto de Salud Carlos III PI20/00879; PI17/01962; FI18/00179; PT20/00018; RD21/0009/0004Italian Department for Anti-Drug Policies ND
6 · The paper itself

Abstract

This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. A total of 48 oral fluid and 12 sweat samples were collected from six consumers. After the addition of 5 μL of methylone-d

Indexed as

Synthetic CathinoneTandem Mass SpectrometryAcetatesGas Chromatography-Mass SpectrometryHumansMethylaminesPentanonesPilot ProjectsPropiophenonesSweatAcetatesclephedroneethyl acetateMethylaminesPentanonespentedronePropiophenonesSynthetic Cathinone4-chloromethcathinonegas-chromatography tandem mass spectrometryN-ethyl hexedroneN-ethyl pentedroneoral fluid pharmacokineticssweatsynthetic cathinones

Identifiers

PMID37298339
PMCPMC10254025
OpenAlexW4378575324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.