Evidence map›Paper›PMID 37298344›Full record

ReviewInternational journal of molecular sciences2023

Impact of Solute Carrier Transporters in Glioma Pathology: A Comprehensive Review.

Filippos Anagnostakis, Michail Kokkorakis, Mariam Markouli, Christina Piperi

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Filippos AnagnostakisDepartment of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-7374-8798
Michail KokkorakisDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-0027-5659
Mariam MarkouliDepartment of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-4630-7337
Christina PiperiDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-2701-0618
Boston University · USNational and Kapodistrian University of Athens · GRUniversity Medical Center Groningen · NLUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solute carriers (SLCs) are essential for brain physiology and homeostasis due to their role in transporting necessary substances across cell membranes. There is an increasing need to further unravel their pathophysiological implications since they have been proposed to play a pivotal role in brain tumor development, progression, and the formation of the tumor microenvironment (TME) through the upregulation and downregulation of various amino acid transporters. Due to their implication in malignancy and tumor progression, SLCs are currently positioned at the center of novel pharmacological targeting strategies and drug development. In this review, we discuss the key structural and functional characteristics of the main SLC family members involved in glioma pathogenesis, along with their potential targeting options to provide new opportunities for CNS drug design and more effective glioma management.

Indexed as

GliomaSolute Carrier ProteinsBiological TransportDrug DesignHumansMembrane Transport ProteinsTumor MicroenvironmentMembrane Transport ProteinsSolute Carrier Proteinsbrain tumorsgliomasSLCsolute carrierstherapytransporterstumor microenvironment

Identifiers

PMID37298344
PMCPMC10253701
OpenAlexW4378619397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.