Evidence map›Paper›PMID 37298541›Full record

ArticleInternational journal of molecular sciences2023

Design, Pharmacological Characterization, and Molecular Docking of Minimalist Peptidomimetic Antagonists of α

Monica Baiula, Michele Anselmi, Francesco Musiani, Alessia Ghidini, Jacopo Carbone, Alberto Caligiana, Andrea Maurizio, Santi Spampinato, Luca Gentilucci

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Monica BaiulaDepartment of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.ORCID 0000-0003-0363-0633
Michele AnselmiDepartment of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Francesco MusianiLaboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, Viale Fanin 40, 40126 Bologna, Italy.ORCID 0000-0003-0200-1712
Alessia GhidiniDepartment of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0003-1063-7067
Jacopo CarboneDepartment of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0002-8743-7859
Alberto CaligianaDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-1836-6882
Andrea MaurizioDepartment of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
Santi SpampinatoDepartment of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
Luca GentilucciDepartment of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0001-9134-3161
University of Bologna · ITBrown University · US

Funding

Cassa di Risparmio in Bologna Fondazione CarisBo project: #18668Ministry of Education, Universities and Research Department of Excellence Program MIUR, L. 232 01/12/2016Ministry of Education, Universities and Research PRIN2020 2020833Y75
6 · The paper itself

Abstract

Integrin receptors mediate cell-cell interactions via the recognition of cell-adhesion glycoproteins, as well as via the interactions of cells with proteins of the extracellular matrix, and upon activation they transduce signals bi-directionally across the cell membrane. In the case of injury, infection, or inflammation, integrins of β

Indexed as

NeoplasmsPeptidomimeticsCell AdhesionHumansIntegrin alpha4beta1Integrin beta1IntegrinsLigandsMolecular Docking SimulationReceptors, Lymphocyte HomingVascular Cell Adhesion Molecule-1Integrin alpha4beta1Integrin beta1IntegrinsLigandsPeptidomimeticsReceptors, Lymphocyte HomingVascular Cell Adhesion Molecule-1antagonistsinflammationleukocytesmolecular modellingpeptidomimeticsVLA-4

Identifiers

PMID37298541
PMCPMC10253817
OpenAlexW4379057036

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.