Evidence map›Paper›PMID 37307402›Full record

ArticleJournal of cellular and molecular medicine2023

Electroacupuncture promotes skin wound repair by improving lipid metabolism and inhibiting ferroptosis.

Weibin Du, Zhenwei Wang, Yi Dong, Huahui Hu, Huateng Zhou, Xiaofen He, Jintao Hu, Yong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Weibin DuResearch Institute of Orthopaedics, the Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Zhejiang, China.ORCID 0000-0002-9698-4897
Zhenwei WangResearch Institute of Orthopaedics, the Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Yi DongShaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University, Zhejiang, China.
Huahui HuResearch Institute of Orthopaedics, the Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Huateng ZhouResearch Institute of Orthopaedics, the Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Xiaofen HeKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, China.
Jintao HuOrthopaedics and Traumatology Department, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Zhejiang, China.
Yong LiResearch Institute of Orthopaedics, the Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Zhejiang Chinese Medical University · CNThe Third Affiliated Hospital of Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid metabolism plays an important role in the repair of skin wounds. Studies have shown that acupuncture is very effective in skin wound repair. However, there is little knowledge about the mechanism of electroacupuncture. Thirty-six SD rats were divided into three groups: sham-operated group, model group and electroacupuncture group, with 12 rats in each group. After the intervention, local skin tissues were collected for lipid metabolomics analysis, wound perfusion and ferroptosis-related indexes were detected and finally the effect of electroacupuncture on skin wound repair was comprehensively evaluated by combining wound healing rate and histology. Lipid metabolomics analysis revealed 37 differential metabolites shared by the three groups, mainly phospholipids, lysophospholipids, glycerides, acylcarnitine, sphingolipids and fatty acids, and they could be back-regulated after electroacupuncture. The recovery of blood perfusion and wound healing was faster in the electroacupuncture group than in the model group (p < 0.05). The levels of GPX4, FTH1, SOD and GSH-PX, which are related to ferroptosis, were higher in the electroacupuncture group than in the model group (p < 0.05). The levels of ACSL4 and MDA were lower in the electroacupuncture group than in the model group (p < 0.05). Electroacupuncture may promote skin wound repair by improving lipid metabolism and inhibiting ferroptosis in local tissues.

Indexed as

ElectroacupunctureFerroptosisAnimalsFatty AcidsLipid MetabolismRatsRats, Sprague-DawleyFatty Acidselectroacupunctureferroptosislipid metabolismoxidative stresswound repair

Identifiers

PMID37307402
PMCPMC10424292
OpenAlexW4380362676

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.