ArticleAdvanced materials (Deerfield Beach, Fla.)2024
Mechanoresponsive Drug Release from a Flexible, Tissue-Adherent, Hybrid Hydrogel Actuator.
Article in Advanced materials (Deerfield Beach, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Programmable Hydrogels for Surgical Interface Control: Function-Based Design, DNA-Based Molecular Modules, and Translational Evaluation.Gels (Basel, Switzerland) · 2026Review
- Multimodal characterization of sustained bioagent release from an epicardial depot for long-term biomaterial incorporation.Biomaterials · 2026Article
- Nano-visualization of hydrogel dynamicsChemical science · 2026Article
- Synergistic Dual Slip-Link Toughening of a Water-Rich Double Network Hydrogel Combining Slide-Ring and Highly Entangled Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Carbon Dot-Based Mechanofluorescent Hydrogel with Tunable Fluorescence for Bioengineering Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Advanced materials and devices strategies of mechanical stimulation for tissue regeneration.Regenerative biomaterials · 2026Review
- A closed-loop microneedle-integrated physiological model for predictive glycemic management.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Immunomodulatory bioadhesive technologies.Biomaterials · 2025Review
- Role of chemistry in nature-inspired skin adhesives.Chemical science · 2025Review
- Antibiotic Action, Drug Delivery, Biodegradability, and Wound Regeneration Characteristics of Surgical Sutures and Cutting-Edge Surgical Suture Manufacturing Technologies.Journal of functional biomaterials · 2025Review
- Actuation-Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bioinspired hydrophobic pseudo-hydrogel for programmable shape-morphing.Nature communications · 2025Article
- Refillable silicone pump with precise switching for timed therapeutic delivery.Frontiers in bioengineering and biotechnology · 2025Article
- Wearable and Implantable Soft Robots.Chemical reviews · 2024Review
- Multiscale crack trapping for programmable adhesives.Science advances · 2024Article
- Magnetic Nanoparticles and Methylprednisolone Based Physico-Chemical Bifunctional Neural Stem Cells Delivery System for Spinal Cord Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Biomedical Applications of Deformable Hydrogel Microrobots.Micromachines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Soft robotic technologies for therapeutic biomedical applications require conformal and atraumatic tissue coupling that is amenable to dynamic loading for effective drug delivery or tissue stimulation. This intimate and sustained contact offers vast therapeutic opportunities for localized drug release. Herein, a new class of hybrid hydrogel actuator (HHA) that facilitates enhanced drug delivery is introduced. The multi-material soft actuator can elicit a tunable mechanoresponsive release of charged drug from its alginate/acrylamide hydrogel layer with temporal control. Dosing control parameters include actuation magnitude, frequency, and duration. The actuator can safely adhere to tissue via a flexible, drug-permeable adhesive bond that can withstand dynamic device actuation. Conformal adhesion of the hybrid hydrogel actuator to tissue leads to improved mechanoresponsive spatial delivery of the drug. Future integration of this hybrid hydrogel actuator with other soft robotic assistive technologies can enable a synergistic, multi-pronged treatment approach for the treatment of disease.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.