Evidence map›Paper›PMID 37310481›Full record

ArticleSkeletal radiology2024

Multifocal osteoclast-rich tumour in Paget bone disease and conventional giant cell tumour, two genetically distinct entities? Sequencing from a single case.

Simon Haefliger, Judith Bubbear, Christropher Davies, Lucia Cottone, Fernanda Amary, Roberto Tirabosco, Isidro Cortes-Ciriano, Paul O'Donnell, Adrienne M Flanagan

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Simon Haefliger *Research Department of Pathology, University College London, UCL Cancer Institute, WC1E 6BT, London, UK.ORCID http://orcid.org/0000-0002-4227-6051
Judith Bubbear *Centre for Metabolic Bone Disease, Royal National Orthopaedic Hospital, Greater London, Stanmore, UK.
Christropher DaviesResearch Department of Pathology, University College London, UCL Cancer Institute, WC1E 6BT, London, UK.
Lucia CottoneResearch Department of Pathology, University College London, UCL Cancer Institute, WC1E 6BT, London, UK.
Fernanda AmaryResearch Department of Pathology, University College London, UCL Cancer Institute, WC1E 6BT, London, UK.
Roberto TiraboscoResearch Department of Pathology, University College London, UCL Cancer Institute, WC1E 6BT, London, UK.
Isidro Cortes-Ciriano *European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK.
Paul O'Donnell *Research Department of Pathology, University College London, UCL Cancer Institute, WC1E 6BT, London, UK.
Adrienne M Flanagan *Research Department of Pathology, University College London, UCL Cancer Institute, WC1E 6BT, London, UK. a.flanagan@ucl.ac.uk.
Royal National Orthopaedic Hospital · GBUniversity College London · GBCancer Research UK · GBEuropean Bioinformatics Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paget disease of bone is a metabolic disorder with a strong genetic component, characterised by pronounced disorganised bone remodelling. Complications of this disease include an increased risk of developing bone neoplasms. Here, we describe the case of a 60-year-old Italian patient with Paget disease of bone, presenting with an osteoclast-rich tumour. Our analysis of this entity, based on the clinical, morphological and genetic data (whole exome sequencing), suggests that osteoclast-rich lesions in Paget disease of bone are genetically distinct from classical giant cell tumour of bone. We discuss the importance of differentiating these osteoclast-rich lesions.

Indexed as

Bone NeoplasmsGiant Cell TumorsOsteitis DeformansBone and BonesGiant CellsHumansMiddle AgedOsteoclastsGeneticsGiant cell tumour of boneOsteoclast-rich tumourPaget disease of boneWhole exome sequencing

Identifiers

PMID37310481
PMCPMC10661784
OpenAlexW4380422669

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.