Evidence map›Paper›PMID 37313177›Full record

ArticleHeliyon2023

Effects of one-year supplementation with

Muhammad Radzi Abu Hassan, Rosaida Hj Md Said, Zalwani Zainuddin, Haniza Omar, Siti Maisarah Md Ali, Siti Aishah Aris, Huan-Keat Chan

Abstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Green Path to Liver Health: Herbal Solutions for Non-alcoholic Steatohepatitis.Cardiovascular & hematological disorders drug targets · 2025
    Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muhammad Radzi Abu HassanClinical Research Centre, Hospital Sultanah Bahiyah, Jalan Langgar, 05460, Alor Setar, Kedah, Malaysia.
Rosaida Hj Md SaidMedical Department, Hospital Ampang, Jalan Mewah Utara, Taman Pandan Mewah, 68000, Ampang Jaya, Selangor, Malaysia.
Zalwani ZainuddinMedical Department, Hospital Sultanah Bahiyah, Jalan Langgar, 05460, Alor Setar, Kedah, Malaysia.
Haniza OmarMedical Department, Hospital Selayang, Jalan Lingkaran Tengah 2, 68100 Batu Caves, Selangor, Malaysia.
Siti Maisarah Md AliClinical Research Centre, Hospital Sultanah Bahiyah, Jalan Langgar, 05460, Alor Setar, Kedah, Malaysia.
Siti Aishah ArisClinical Research Centre, Hospital Sultanah Bahiyah, Jalan Langgar, 05460, Alor Setar, Kedah, Malaysia.
Huan-Keat ChanClinical Research Centre, Hospital Sultanah Bahiyah, Jalan Langgar, 05460, Alor Setar, Kedah, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: and purpose: Non-alcoholic fatty liver disease (NAFLD) is a significant global health concern with limited pharmacotherapy options. This study aimed to evaluate the effectiveness of a standardized extract of Materials and methods: This was a 12-month randomized controlled trial, in which adults with a controlled attenuation parameter (CAP) score >250 dB/m and a fibrosis score <10 kPa were randomly assigned to receive a standardized Results: After 12 months, there was no significant difference in the change of CAP score between the intervention and control groups (-15.05 ± 36.76 dB/m vs. -14.74 ± 41.08 dB/m; p = 0.869). There was also no significant difference in the changes of liver enzyme levels between the two groups. However, the intervention group showed a significant reduction in fibrosis score, which was not observed in the control group (-0.64 ± 1.66 kPa versus 0.10 ± 1.61 kPa; p = 0.001). No major adverse events were reported in either group. Conclusion: This study showed that

Indexed as

FibrosisHerbal medicineLiver cirrhosisNon-alcoholic fatty liver diseasePhyllanthus

Identifiers

PMID37313177
PMCPMC10258366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.