Evidence mapPaperPMID 37313202Full record

ArticleArchives of medical science : AMS2023

Natural and natural-like polyphenol compounds:

Jasmina Brboric, Aleksandra Klisic, Jelena Kotur-Stevuljevic, Giovanna Delogu, Darinka Gjorgieva Ackova, Kristina Kostic, Maria Antonietta Dettori, Davide Fabbri, Paola Carta, Luciano Saso

Abstract read
In one paragraph

Article in Archives of medical science : AMS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jasmina BrboricDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia, Serbia.
Aleksandra KlisicPrimary Health Care Center, University of Montenegro, Faculty of Medicine, Podgorica, Montenegro, Montenegro.
Jelena Kotur-StevuljevicDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia, Serbia.
Giovanna DeloguCNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy.
Darinka Gjorgieva AckovaFaculty of Medical Sciences, Goce Delcev University, Stip, Republic of North Macedonia, North Macedonia.
Kristina KosticDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia, Serbia.
Maria Antonietta DettoriCNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy.
Davide FabbriCNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy.
Paola CartaCNR - Institute of Biomolecular Chemistry, Sassari, Italy, Italy.
Luciano SasoDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Italy, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Phenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to perform Material and methods: Antioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were evaluated Results: In an assay consisting of pooled human serum, 6 of the 36 compounds showed significant antioxidant activity (compounds 6, 7, 12, 13, 26, and 27), whereas 4 showed extremely weak antioxidant activity (compounds 2, 29, 30, and 31). Within the 36 compounds comprising zingerone, dehydrozingerone, aurone, chalcone, and magnolol derivatives, in both monomeric and dimeric forms, the 2 compounds that indicated the highest antioxidant activity were dehydrozingerone derivatives (compounds 6 and 12). Trolox's activity was found between the strong and weak antioxidant compounds analysed in our study. Conclusions: In this study selected dehydrozingerones were identified as good candidates for in-depth testing of their biological behaviour and for possible precursors for synthesis of novel polyphenolic molecules with potential therapeutic applications.

Indexed as

dehydrozingeronehydroxylated biphenylsoxidative stresspolyphenolsTrolox

Identifiers

PMID37313202
PMCPMC10259401

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.