ArticleBJPsych open2023
Autonomic dysregulation, cognition and fatigue in people with depression and in active and healthy controls: observational cohort study.
Article in BJPsych open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2026Article
- Mechanistic insights into the liver-brain axis during chronic liver disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Association between depression and cardiometabolic multimorbidity: A protocol for a systematic review and meta-analysis.PloS one · 2026Article
- Prescreening depression using wearable electrocardiogram and photoplethysmogram data from a psycholinguistic experiment.Physiological measurement · 2025Article
- Brain functional connectivity after Stroop task induced cognitive fatigue.Scientific reports · 2025Article
- Understanding cognitive control in depression: the interactive role of emotion, expected efficacy and reward.BMC psychiatry · 2025Article
- Evaluating the Associations Among Dysautonomia, Gastrointestinal Transit, and Clinical Phenotype in Patients With Systemic Sclerosis.Arthritis care & research · 2024Article
- Adjustment Disorder Presenting as Syncope in a Patient With Wolf-Parkinson White Syndrome.Cureus · 2024Article
- Article
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2024Article
- Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data.Research in autism spectrum disorders · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAutonomic nervous system (ANS) dysregulation might be relevant to the pathophysiology of fatigue and cognitive impairment in depression and perhaps should be considered when making prescribing decisions.
aimsTo determine the relationship of self-reported ANS symptoms with fatigue, cognition and prescribed medication in people with a diagnosis of depression, in comparators without depression but with other mental health, neurodevelopmental or neurodegenerative disorders (active controls) and in healthy controls.
methodCross-sectional analysis of an opportunistic sample from England. Self-reported data were collected on demographics, diagnosis, medication, ANS symptoms (Composite Autonomic Symptom Scale-31, COMPASS-31) and fatigue (Visual Analogue Scale for Fatigue, VAS-F). A subsample completed cognitive tests (THINC-it), including the subjective Perceived Deficits Questionnaire five-item version (PDQ-5). Spearman's correlation and mediation models were used to explore the relationship between COMPASS-31, VAS-F and PDQ-5 scores.
resultsData were obtained for 3345 participants, 22% with depression. The depression group had significantly (
conclusionsPeople with a diagnosis of depression report worse fatigue and cognition than active and healthy comparators; this appears to be mediated by ANS dysregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.