Evidence map›Paper›PMID 37315007›Full record

ArticlePloS one2023

Examining decisional needs and contextual factors influencing fertility status assessment among young female survivors of childhood cancer: A sequential mixed methods study protocol.

Brooke Cherven, Nataliya V Ivankova, Jessica B Spencer, Anne M Fitzpatrick, Karen C Burns, Jenna Demedis, Holly R Hoefgen, Ann C Mertens, James L Klosky

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Brooke ChervenAflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, Atlanta, GA, United States of America.ORCID 0000-0002-5978-655X
Nataliya V IvankovaDepartment of Health Services Administration, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Jessica B SpencerDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, United States of America.
Anne M FitzpatrickDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America.
Karen C BurnsUniversity of Cincinnati College of Medicine, Cincinnati, OH, United States of America.
Jenna DemedisCenter for Cancer and Blood Disorders at Children's Hospital Colorado, Aurora, CO, United States of America.ORCID 0000-0001-5191-7511
Holly R HoefgenAflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, Atlanta, GA, United States of America.
Ann C MertensAflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, Atlanta, GA, United States of America.
James L KloskyAflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, Atlanta, GA, United States of America.
Emory University · USChildren's Hospital Colorado · USCincinnati Children's Hospital Medical Center · USUniversity of Alabama at Birmingham · USWashington University in St. Louis · US

Funding

A mixed methods approach to examining decisional needs and contextual factors influencing fertility status assessment outcomes among young female survivors of childhood cancer.K23NR020037 · NINR · EMORY UNIVERSITY · PI CHERVEN, BROOKE OAKLEY · 2021 to 2023
$469k
NINR NIH HHS K23 NR020037
6 · The paper itself

Abstract

introductionFemale cancer survivors who received gonadotoxic cancer treatment are at risk for profound diminished ovarian reserve and/or primary ovarian insufficiency with resulting infertility, which can be associated with distress and decreased quality of life.. Despite prioritizing future parenthood, many survivors are unsure of the impact of their treatment on their future fertility, and little is known about the perceived reproductive health needs and factors associated with receipt of a fertility status assessment (FSA). There is a lack of developmentally appropriate reproductive health decisional support interventions available for emerging adult cancer survivors. This study will explore the perceived reproductive health needs of emerging adult female survivors of childhood cancer and to identify decisional and contextual factors that influence pursuit of FSA using an explanatory sequential quantitative to qualitative mixed methods design. METHODS AND ANALYSIS: This study will enroll 325 female survivors (aged 18 to 29 years and >1-year post treatment; diagnosed with cancer < age 21 years) from four cancer centers in the United States. Sociodemographic and developmental factors, reproductive knowledge and values, decisional needs, and receipt of an FSA will be assessed through a web-based survey. Informed by survey findings, a subset of participants will be recruited for qualitative interviews to explore decisional factors associated with uptake of an FSA. Clinical data will be abstracted from the medical records. Multivariable logistic regression models will be developed to identify factors associated with FSA and qualitative descriptive analysis will be used to develop themes from the interviews. Quantitative and qualitative findings will be merged using a joint display to develop integrated study conclusions and direct future interventional research.

Indexed as

Cancer SurvivorsNeoplasmsAdultChildFemaleFertilityHumansQuality of LifeSurvivors

Identifiers

PMID37315007
PMCPMC10266625
OpenAlexW4380628444

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.