Evidence map›Paper›PMID 37317882›Full record

ReviewJournal of neuroendocrinology2023

Neuroendocrine mechanism of gastric acid secretion: Historical perspectives and recent developments in physiology and pharmacology.

Duan Chen, Susan J Hagen, Malcolm Boyce, Chun-Mei Zhao

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of neuroendocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Medicinal Ingredients of Wax Gourd (Plants (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Review
  5. Advances in peptide modulation in systems physiology.Journal of neuroendocrinology · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Duan ChenDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-3429-4580
Susan J HagenDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2731-3264
Malcolm BoyceHammersmith Medicines Research Ltd, London, UK.ORCID 0000-0001-8807-612X
Chun-Mei ZhaoDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0009-0001-3559-3884
Norwegian University of Science and Technology · NOBeth Israel Deaconess Medical Center · USHammersmith Medicines Research · GB

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLDR01DK103046 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAVID E. COHEN, Susan J Hagen · 2015 to 2026
$7.6M
NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK103046NIH HHS NIH P30 DK034854NIH HHS NIH RO1 DK103046
6 · The paper itself

Abstract

The physiology of gastric acid secretion is one of the earliest subjects in medical literature and has been continuously studied since 1833. Starting with the notion that neural stimulation alone drives acid secretion, progress in understanding the physiology and pathophysiology of this process has led to the development of therapeutic strategies for patients with acid-related diseases. For instance, understanding the physiology of parietal cells led to the developments of histamine 2 receptor blockers, proton pump inhibitors (PPIs), and recently, potassium-competitive acid blockers. Furthermore, understanding the physiology and pathophysiology of gastrin has led to the development of gastrin/CCK

Indexed as

Gastric AcidGastrinsAnimalsHumansMiceParietal Cells, GastricProton Pump InhibitorsReceptor, Cholecystokinin BGastrinsProton Pump InhibitorsReceptor, Cholecystokinin Bgastringene targetingnetazepidepotassium-competitive acid blockers

Identifiers

PMID37317882
PMCPMC10656367
OpenAlexW4377099001

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.