ArticleThe European respiratory journal2023
Nasal airway microRNA profiling of infants with severe bronchiolitis and risk of childhood asthma: a multicentre prospective study.
Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 30 citations in OpenAlex.
- Association between nasal airway metabolome signatures and lung function at age 6 years among children with post-bronchiolitis asthma.ERJ open research · 2026Article
- Infancy IgE methylation score and childhood wheezing and asthma: Multicohort study.The Journal of allergy and clinical immunology · 2026Article
- Interactions between host genetics and gut microbiome influence susceptibility to childhood asthma and lung function.The Journal of allergy and clinical immunology · 2026Article
- Nasopharyngeal Microbiome-Epigenome-Wide Association Analysis in Infants With Severe Bronchiolitis.Allergy · 2026Article
- From symptoms to mechanisms: multidimensional insights into cannabis smoke.The European respiratory journal · 2026Article
- MMRV vaccine safety: A comprehensive analysis of adverse events recorded among pediatric populations.Human vaccines & immunotherapeutics · 2025Article
- Review
- Functional sequence variants of intergenic long noncoding RNA on chromosome 17q21 are associated with asthma.The European respiratory journal · 2025Article
- Gene-environment interaction at 17q12-q21 locus and its role in asthma pathogenesis.The European respiratory journal · 2025Article
- microRNA Biomarkers in Paediatric Infection Diagnostics-Bridging the Gap Between Evidence and Clinical Application: A Scoping Review.Non-coding RNA · 2025Review
- Heterogeneity and molecular mechanisms of early-life wheeze.The Journal of allergy and clinical immunology · 2025Article
- Early-life wheeze trajectories are associated with distinct asthma transcriptomes later in life.The Journal of allergy and clinical immunology · 2025Article
- Unraveling the Molecular Complexity of Asthma: Insights from a Multicohort Transcriptome Study.American journal of respiratory cell and molecular biology · 2025Article
- Multicohort Analysis of Bronchial Epithelial Cell Expression in Healthy Subjects and Patients with Asthma Reveals Four Clinically Distinct Clusters.American journal of respiratory cell and molecular biology · 2025Article
- Non-T2 asthma.Current opinion in pulmonary medicine · 2025Review
- DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples.Epigenetics & chromatin · 2025Article
- Precision medicine for asthma treatment: Unlocking the potential of the epigenome and microbiome.The Journal of allergy and clinical immunology · 2025Review
- Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma.The European respiratory journal · 2024Article
- Association between nasopharyngeal airway lipidome signatures of infants with severe bronchiolitis and risk of recurrent wheeze: A prospective multicenter cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Salivary polyreactive antibodies andThe European respiratory journal · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSevere bronchiolitis (
methodsIn a 17-centre prospective cohort study of infants with severe bronchiolitis, we sequenced their nasal microRNA at hospitalisation. First, we identified differentially expressed microRNAs (DEmiRNAs) associated with the risk of developing asthma by age 6 years. Second, we characterised the DEmiRNAs based on their association with asthma-related clinical features, and expression level by tissue and cell types. Third, we conducted pathway and network analyses by integrating DEmiRNAs and their mRNA targets. Finally, we investigated the association of DEmiRNAs and nasal cytokines.
resultsIn 575 infants (median age 3 months), we identified 23 DEmiRNAs associated with asthma development (
conclusionIn a multicentre cohort of infants with severe bronchiolitis, we identified nasal miRNAs during illness that were associated with major asthma-related clinical features, immune response, and risk of asthma development.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.