Evidence map›Paper›PMID 37322156›Full record

ArticleNature chemical biology2023

Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo.

Mijin Kim, Chen Chen, Zvi Yaari, Rune Frederiksen, Ewelina Randall, Jaina Wollowitz, Christian Cupo, Xiaojian Wu, Janki Shah, Daniel Worroll and 6 more

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 73 citations in OpenAlex.

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  11. High-throughput SWCNT NIR-II screening enables cell andbioRxiv : the preprint server for biology · 2026
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  19. Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Mijin Kim *Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7781-9466
Chen Chen *Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4803-0183
Zvi YaariMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Rune FrederiksenMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Ewelina RandallMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Jaina WollowitzMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Christian CupoMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Xiaojian WuDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Janki ShahMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Daniel WorrollMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Rachel E LagenbacherMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Dana GoerzenMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9645-3503
Yue-Ming LiMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-2633-3730
Heeseon AnMemorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-8518-4077
YuHuang WangDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Daniel A HellerMemorial Sloan Kettering Cancer Center, New York, NY, USA. hellerd@mskcc.org.ORCID 0000-0002-6866-0000
Memorial Sloan Kettering Cancer Center · USUniversity of Maryland, College Park · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
CANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1M
Predoctoral Training in Pharmacological SciencesT32GM073546 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GROSS, STEVEN S · 2006 to 2020
$3.1M
P-selectin-Mediated Targeting of PI3K Nanomedicines to the Tumor MicroenvironmentR01CA215719 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HELLER, DANIEL ALAN · 2018 to 2022
$3.1M
Transient Metabolite Detection for Single-Cell Metabolomics and DiagnosticsDP2HD075698 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI HELLER, DANIEL ALAN · 2012 to 2012
$2.7M
Predoctoral Training in Pharmacological SciencesT32GM141949 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kristen Elizabeth Pleil · 2021 to 2026
$2.5M
Tri-Institutional PhD Program in Chemical BiologyT32GM136640 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEREK S TAN · 2020 to 2026
$2.4M
Machine Perception Nanosensor Array Platform to Capture Whole Disease Fingerprints of Early Stage Pancreatic CancerK99EB033580 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI KIM, MIJIN · 2022 to 2023
$199k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA215719NCI NIH HHS T32 CA062948NIBIB NIH HHS K99 EB033580NICHD NIH HHS DP2 HD075698NIGMS NIH HHS T32 GM073546NIGMS NIH HHS T32 GM136640NIGMS NIH HHS T32 GM141949
6 · The paper itself

Abstract

Autophagy is a cellular process with important functions that drive neurodegenerative diseases and cancers. Lysosomal hyperacidification is a hallmark of autophagy. Lysosomal pH is currently measured by fluorescent probes in cell culture, but existing methods do not allow for quantitative, transient or in vivo measurements. In the present study, we developed near-infrared optical nanosensors using organic color centers (covalent sp

Indexed as

Nanotubes, CarbonAutophagyHydrogen-Ion ConcentrationLysosomesMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 1Nanotubes, Carbon

Identifiers

PMID37322156
PMCPMC10721723
OpenAlexW4380714888

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.