Evidence map›Paper›PMID 37323487›Full record

ArticleInternational journal of bioprinting2023

Feasibility of 3D-printed middle ear prostheses in partial ossicular chain reconstruction.

Anssi-Kalle Heikkinen, Sini Lähde, Valtteri Rissanen, Mika Salmi, Antti A Aarnisalo, Antti Mäkitie, Ville Sivonen, Saku T Sinkkonen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bioprinting, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Investigation of the coupling quality of partial prostheses at the stapes head.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anssi-Kalle HeikkinenDepartment of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Sini LähdeDepartment of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Valtteri RissanenDepartment of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Mika SalmiDepartment of Mechanical Engineering, Aalto University, Espoo, Finland.
Antti A AarnisaloDepartment of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Ville SivonenDepartment of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Saku T SinkkonenDepartment of Otorhinolaryngology-Head and Neck Surgery and Tauno Palva Laboratory, Head and Neck Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Helsinki University Hospital · FIAalto University · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in prosthesis materials, operating microscopes and surgical techniques during the last 50 years, long-lasting hearing improvement remains a challenge in ossicular chain reconstruction. Failures in the reconstruction are mainly due to inadequate length or shape of the prosthesis, or defects in the surgical procedure. 3D-printed middle ear prosthesis might offer a solution to individualize treatment and obtain better results. The aim of the study was to study the possibilities and limitations of 3D-printed middle ear prostheses. Design of the 3D-printed prosthesis was inspired by a commercial titanium partial ossicular replacement prosthesis. 3D models of different lengths (1.5-3.0 mm) were created with Solidworks 2019-2021 software. The prostheses were 3D-printed with vat photopolymerization using liquid photopolymer Clear V4. Accuracy and reproducibility of 3D printing were evaluated with micro-CT imaging. The acoustical performance of the prostheses was determined in cadaver temporal bones with laser Doppler vibrometry. In this paper, we present an outline of individualized middle ear prosthesis manufacturing. 3D printing accuracy was excellent when comparing dimensions of the 3D-printed prostheses and their 3D models. Reproducibility of 3D printing was good if the diameter of the prosthesis shaft was 0.6 mm. 3D-printed partial ossicular replacement prostheses were easy to manipulate during surgery even though they were a bit stiffer and less flexible than conventional titanium prostheses. Their acoustical performance was similar to that of a commercial titanium partial ossicular replacement prosthesis. It is possible to 3D print functional individualized middle ear prostheses made of liquid photopolymer with good accuracy and reproducibility. These prostheses are currently suitable for otosurgical training. Further research is needed to explore their usability in a clinical setting. In the future, 3D printing of individualized middle ear prostheses may provide better audiological outcomes for patients.

Indexed as

3D printingLaser Doppler vibrometryMiddle ear transfer functionOssicular chain reconstructionPartial ossicular replacement prosthesisTotal ossicular replacement prosthesis

Identifiers

PMID37323487
PMCPMC10261128
OpenAlexW4362700071

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.