Evidence map›Paper›PMID 37324242›Full record

ArticleBrain communications2023

Less is more in language production: an information-theoretic analysis of agrammatism in primary progressive aphasia.

Neguine Rezaii, Boyu Ren, Megan Quimby, Daisy Hochberg, Bradford C Dickerson

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Word Count Matters: Features of Written Language Production in Progressive Apraxia of Speech with and without Agrammatism.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2025
    Article
  4. Language abnormalities in Alzheimer's disease indicate reduced informativeness.Annals of clinical and translational neurology · 2024
    Article
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Neguine RezaiiFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Boyu RenDepartment of Psychiatry, Laboratory for Psychiatric Biostatistics, McLean Hospital, Belmont, MA 02478, USA.
Megan QuimbyFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Daisy HochbergFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Bradford C DickersonFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
Massachusetts General Hospital · USHarvard University · USMcLean Hospital · US

Funding

Imaging tau, amyloid, and neurodegeneration in PPAR01DC014296 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, JOHNSON, KEITH A. · 2016 to 2020
$4.3M
SPEECH MOVEMENT CLASSIFICATION FOR ASSESSING AND TREATING ALSR01DC013547 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI GREEN, JORDAN R · 2014 to 2018
$3.2M
Use of machine learning to quantify cognitive function in AD, FTD, and DLBR21AG073744 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, WOLFF, PHILLIP MARK · 2021 to 2022
$443k
Computational psycholinguistic analysis of speech samples in PPA and AD and FTDR21DC019567 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, WOLFF, PHILLIP MARK · 2022 to 2023
$443k
NIA NIH HHS R21 AG073744NIDCD NIH HHS R01 DC013547NIDCD NIH HHS R01 DC014296NIDCD NIH HHS R21 DC019567
6 · The paper itself

Abstract

Agrammatism is a disorder of language production characterized by short, simplified sentences, the omission of function words, an increased use of nouns over verbs and a higher use of heavy verbs. Despite observing these phenomena for decades, the accounts of agrammatism have not converged. Here, we propose and test the hypothesis that the lexical profile of agrammatism results from a process that opts for words with a lower frequency of occurrence to increase lexical information. Furthermore, we hypothesize that this process is a compensatory response to patients' core deficit in producing long, complex sentences. In this cross-sectional study, we analysed speech samples of patients with primary progressive aphasia (

Indexed as

agrammatismentropyinformation theoryprimary progressive aphasiaword frequency

Identifiers

PMID37324242
PMCPMC10263269
OpenAlexW4366983268

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.