Evidence map›Paper›PMID 37324924›Full record

ArticleFood science & nutrition2023

Adjunctive nano-curcumin therapy improves inflammatory and clinical indices in children with cystic fibrosis: A randomized clinical trial.

Saeedeh Talebi, Andrew S Day, Mahammad Safarian, Seyed Javad Sayedi, Mahmood Reza Jaafari, Zahra Abbasi, Hanieh Barghchi, Hamid Reza Kianifar

Open access · hybridAbstract read
In one paragraph

Article in Food science & nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Saeedeh TalebiDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Andrew S DayDepartment of Pediatrics University of Otago Christchurch New Zealand.
Mahammad SafarianDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Seyed Javad SayediDepartment of Pediatrics Mashhad University of Medical Sciences Mashhad Iran.
Mahmood Reza JaafariNanotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences Mashhad Iran.
Zahra AbbasiAkbar Clinical Research and Development Unit Mashhad University of Medical Sciences Mashhad Iran.
Hanieh BarghchiDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.ORCID https://orcid.org/0000-0002-3503-5540
Hamid Reza KianifarDepartment of Pediatrics Mashhad University of Medical Sciences Mashhad Iran.ORCID https://orcid.org/0000-0003-1881-1525
Mashhad University of Medical Sciences · IRUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation may develop due to internal dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein or external factors in patients with cystic fibrosis (CF). This prospective randomized clinical trial aimed to ascertain the effects of nano-curcumin as an anti-inflammatory agent and a CFTR modulator on clinical and inflammatory markers in children with CF. Children with CF were randomly assigned to receive daily curcumin or a placebo for 3 months. The primary outcome measure was to evaluate inflammatory indices, nasopharyngeal swab analysis, and clinical assessments via spirometry, anthropometric measurements, and quality of life (QOL) analysis. Sixty children were included. Intra-group changes comparison showed that curcumin decreased the level of high-sensitivity C-reactive protein (hs-CRP) (median: -0.31 mg/L, IQR: -1.53 to 0.81;

Indexed as

childcurcumincystic fibrosisinflammationtreatment outcome

Identifiers

PMID37324924
PMCPMC10261803
OpenAlexW4361212012

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.