ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2023
STING deficiency protects against wasp venom-induced acute kidney injury.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Snake envenomation and acute kidney injury: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- The predictive value of early systemic inflammatory response index (SIRI), serum βRenal failure · 2026Article
- Transcriptome-Metabolome Integration Deciphers the Metabolic and Transcriptional Reprogramming in Mice Due toToxins · 2026Article
- Emerging Mechanistic Roles of STING Signaling in Kidney Diseases.The American journal of pathology · 2026Review
- From sting to STING: role of inflammation in wasp sting induced AKI - a narrative review.BMC nephrology · 2025Review
- The role of mitochondrial reactive oxygen species in initiating mitochondrial damage and inflammation in wasp-venom-induced acute kidney injury.Journal of toxicologic pathology · 2025Article
- Complement activation in wasp venom-induced acute kidney injury.Renal failure · 2024Article
- The association between procalcitonin and acute kidney injury in patients stung by wasps.Frontiers in physiology · 2023Article
- Wasp venom-induced acute kidney injury: current progress and prospects.Renal failure · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveRecent evidence suggests a key role of the inflammatory responses in wasp venom-induced acute kidney injury (AKI). However, the potential regulatory mechanisms underlying the inflammatory responses in wasp venom-induced AKI remain unclear. STING reportedly plays a critical role in other AKI types and is associated with inflammatory responses and diseases. We aimed to investigate the involvement of STING in inflammatory responses associated with wasp venom-induced AKI.
methodsThe role of the STING signaling pathway in wasp venom-induced AKI was studied in vivo using a mouse model of wasp venom-induced AKI with STING knockout or pharmacological inhibition and in vitro using human HK2 cells with STING knockdown.
resultsSTING deficiency or pharmacological inhibition markedly ameliorated renal dysfunction, inflammatory responses, necroptosis, and apoptosis in wasp venom-induced AKI in mice. Moreover, STING knockdown in cultured HK2 cells attenuated the inflammatory response, necroptosis, and apoptosis induced by myoglobin, the major pathogenic factor in wasp venom-induced AKI. Urinary mitochondrial DNA upregulation has also been observed in patients with wasp venom-induced AKI.
conclusionsSTING activation mediates the inflammatory response in wasp venom-induced AKI. This may offer a potential therapeutic target for the management of wasp venom-induced AKI.
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