Evidence map›Paper›PMID 37330509›Full record

ReviewBMC women's health2023

Intrahepatic cholestasis of pregnancy after ovarian hyperstimulation syndrome with wild-type ABCB4 gene: a peculiar case and literature review.

Loris Marin, Guido Ambrosini, Ludovica Nuzzi, Giovanni Buzzaccarini, Federica Esposito, Giampiero Capobianco, Vito Chiantera, Antonio Simone Laganà, Alessandra Andrisani

Open access · goldAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC women's health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Intrahepatic cholestasis of pregnancy.Nature reviews. Disease primers · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Loris MarinDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Guido AmbrosiniDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Ludovica NuzziDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Giovanni BuzzaccariniObstetrics and Gynaecology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Federica EspositoDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Giampiero CapobiancoDepartment of Surgical, Microsurgical and Medical Sciences, Gynecologic and Obstetric Clinic, University of Sassari, Sassari, Italy.
Vito ChianteraUnit of Gynecologic Oncology, ARNAS "Civico - Di Cristina - Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Piazza Nicola Leotta 4, 90127, Palermo, Italy.
Antonio Simone LaganàUnit of Gynecologic Oncology, ARNAS "Civico - Di Cristina - Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Piazza Nicola Leotta 4, 90127, Palermo, Italy. antoniosimone.lagana@unipa.it.ORCID 0000-0003-1543-2802
Alessandra AndrisaniDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
University of Padua · ITDepartment of Health · ESUniversity of Sassari · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntrahepatic cholestasis of pregnancy (ICP) in the first trimester occurring after ovarian hyperstimulation syndrome (OHSS) is a rare condition and few cases are reported in the literature. Hyperestrogenism may explain this problem in genetically predisposed women. The objective of this article is to report one of these rare cases and offer an overview of the other published cases. CASE PRESENTATION: We report a case of severe OHSS followed by ICP in the first trimester. The patient was admitted to the intensive care unit and was treated according to the guidelines for the management of OHSS. Moreover, the patient also received ursodeoxycholic acid for ICP, which brought to an improvement of her clinical conditions. The pregnancy continued without other complications until the 36

conclusionsICP in the first trimester might be induced by elevated serum estrogen levels after OHSS in genetically predisposed women. In these women, it might be useful to check for genetic polymorphisms to know if they have a predisposition for ICP recurrence in the third trimester of pregnancy.

Indexed as

Cholestasis, IntrahepaticOvarian Hyperstimulation SyndromePregnancy ComplicationsCesarean SectionFemaleGenetic Predisposition to DiseaseHumansInfant, NewbornPregnancyFirst trimesterGenetic polymorphismsIntrahepatic cholestasis of pregnancyIn vitro fertilizationOvarian hyperstimulation syndrome

Identifiers

PMID37330509
PMCPMC10276903
OpenAlexW4381051741

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.