Evidence map›Paper›PMID 37330524›Full record

ArticleNature communications2023

The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice.

Aaron Warren, Ryan M Porter, Olivia Reyes-Castro, Md Mohsin Ali, Adriana Marques-Carvalho, Ha-Neui Kim, Landon B Gatrell, Ernestina Schipani, Intawat Nookaew, Charles A O'Brien and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. A sustained NADBioactive materials · 2026
    Article
  2. Article
  3. Article
  4. Metabolic Plasticity in Embryogenesis Throughout the Lens of NADMethods in molecular biology (Clifton, N.J.) · 2026
    Review
  5. Article
  6. Article
  7. NADProgress in orthodontics · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Aaron Warren *Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-0042-9021
Ryan M Porter *Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-0246-5747
Olivia Reyes-CastroDivision of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Md Mohsin AliDivision of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Adriana Marques-CarvalhoCNC-Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, Cantanhede, Portugal.
Ha-Neui KimDivision of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0003-2498-6700
Landon B GatrellDivision of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Ernestina SchipaniDepartment of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Intawat NookaewCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0001-8901-1088
Charles A O'BrienDivision of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Roy MorelloCenter for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0003-1604-4879
Maria AlmeidaDivision of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR, USA. schullermaria@uams.edu.ORCID 0000-0002-6722-9200
University of Arkansas for Medical Sciences · USBiocant · PTUniversity of Arkansas Medical Center · USUniversity of Pennsylvania · US

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI CHARLES A O'BRIEN · 2018 to 2026
$23.0M
Role of FoxOs in Skeletal Homeostasis- ResubmissionR01AR056679 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI ALMEIDA, MARIA JOSE · 2010 to 2020
$3.6M
Mitochondria and TFAM in Osteoblast BiologyR01AR074079 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SCHIPANI, ERNESTINA · 2019 to 2024
$2.0M
Different consequences of cellular aging in cortical versus cancellous bone- ResubmissionR01AG068449 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI ALMEIDA, MARIA JOSE, O'BRIEN, CHARLES A · 2021 to 2025
$1.9M
Mechanisms of decreased bone formation with agingR56AR056679 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI ALMEIDA, MARIA JOSE · 2022 to 2022
$455k
NIAMS NIH HHS R01 AR056679NIAMS NIH HHS R01 AR074079NIAMS NIH HHS R56 AR056679NIA NIH HHS R01 AG068449NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

NAD is an essential co-factor for cellular energy metabolism and multiple other processes. Systemic NAD

Indexed as

Energy MetabolismNADAnimalsCytokinesHomeostasisHumansMiceMice, KnockoutOxidation-ReductionCytokinesNAD

Identifiers

PMID37330524
PMCPMC10276814
OpenAlexW4381093857

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.