ArticleNature communications2023
Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
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Who cites it
25 citing papers in PubMed, 27 citations in OpenAlex.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Bidirectional regulation by BACH2 coordinates systemic CXCR5- vs. CXCR5+ CD4+ T cell differentiation.The Journal of experimental medicine · 2026Article
- Mechanisms of T cell activation: Integrating signaling pathways, experimental models, and therapeutic implications.EXCLI journal · 2026Review
- Follicular T cells in the ovarian cancer immune microenvironment: biological insights and translational implications.Frontiers in immunology · 2026Review
- Multimodal analysis definesbioRxiv : the preprint server for biology · 2025Article
- Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity.Nature immunology · 2025Article
- Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis.Immunology · 2025Article
- Dynamics of tertiary lymphoid structures and immune cross talk in early versus advanced colorectal cancer: potential implications for immunotherapy.Cancer immunology, immunotherapy : CII · 2025Article
- The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation.JCI insight · 2025Article
- STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis.Investigative ophthalmology & visual science · 2025Article
- TIGIT Regulates T Cell Inflammation in Airway Inflammatory Diseases.Inflammation · 2025Review
- Platelets as a potential new immune coordinator in T cell-mediated aplastic anemia.Frontiers in oncology · 2025Review
- Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Advances and challenges in identifying precursors of memory CD4Frontiers in immunology · 2025Review
- Human axillary lymph node T follicular helper (Tfh) and Precursor-Tfh cells exhibit functional flexibility following seasonal influenza vaccination.Clinical & translational immunology · 2025Article
- Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics.Frontiers in immunology · 2025Review
- Transcription factor c-Maf: a checkpoint that programs autoimmunity.Frontiers in immunology · 2025Review
- Follicular Helper T Cells: Potential Interventional Targets in Atherosclerosis.Journal of immunology research · 2025Review
- Synergistic blockade of TIGIT and PD-L1 increases type-1 inflammation and improves parasite control during murine blood-stageInfection and immunity · 2024Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Fangming Zhu *Department of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0001-7805-6969
Ryan J McMonigle *Department of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Andrew R SchroederDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Xianyou XiaDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
David FiggeDepartment of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Braxton D GreerDepartment of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Edahí González-AvalosDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.
Diego O SialerDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0001-5974-8273
Yin-Hu WangDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0002-3637-8852
Kelly M ChandlerDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Adam J GetzlerDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, 33458, USA.
Emily R BrownDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Changchun XiaoDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0000-0001-8754-3208
Olaf KutschDepartment of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Yohsuke HaradaFaculty of Pharmaceutical Sciences, Tokyo, University of Science, Chiba, 278-8510, Japan.ORCID 0000-0002-8023-1030
Matthew E PipkinDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, 33458, USA.ORCID 0000-0002-9688-0190
Hui HuDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. huihu@uab.edu.ORCID 0000-0002-2915-7189
University of Alabama at Birmingham · USScripps Research Institute · USLa Jolla Institute for Immunology · USTokyo University of Science · JP
Funding
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8MIMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1MTranscription factor regulation of CD4 and CD8 T cell effector and memory differentiation and functionP01AI145815 · NIAID · UNIVERSITY OF FLORIDA · PI PIPKIN, MATTHEW EUGENE · 2020 to 2024
$11.0MTraining Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6MOvercoming HIV-1 transcriptional latency in unresponsive CD4 T cellsR01AI122842 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2017 to 2020
$2.6MRegulation of Tfh cell differentiation and humoral immunityR01AI130232 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HU, HUI · 2017 to 2021
$2.6MIdentification of drugs that induce terminal transcriptional silencing of latent HIV-1 infectionR61AI133679 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2017 to 2019
$2.0MIdentification of drugs that induce terminal transcriptional silencing of latent HIV-1 infectionR33AI133679 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2020 to 2021
$1.4MKinomic analysis of host cell factors controlling latent HIV-1 infectionR33AI116188 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2016 to 2018
$1.3MKinomic analysis of host cell factors controlling latent HIV-1 infectionR21AI116188 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2014 to 2015
$551kOvercoming HIV-1 transcriptional latency in unresponsive CD4 T cellsR56AI122842 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2016 to 2016
$455kNIAID NIH HHS P01 AI145815NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI122842NIAID NIH HHS R01 AI130232NIAID NIH HHS R21 AI116188NIAID NIH HHS R21 AI161774NIAID NIH HHS R33 AI116188NIAID NIH HHS R33 AI133679NIAID NIH HHS R56 AI122842NIAID NIH HHS R56 AI167986NIAID NIH HHS R61 AI133679NIAID NIH HHS T32 AI007051NIAMS NIH HHS T32 AR069516NIGMS NIH HHS T32 GM008361
Abstract
Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1
Indexed as
T Follicular Helper CellsT-Lymphocytes, Helper-InducerCell DifferentiationGerminal CenterProgrammed Cell Death 1 ReceptorReceptors, CXCR5Programmed Cell Death 1 ReceptorReceptors, CXCR5
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.