Evidence map›Paper›PMID 37330941›Full record

ArticleMolecular biology reports2023

Dopamine receptors gene overexpression in the microenvironment of invasive gastric cancer and its potential implications.

Omolbanin Amjadi, Akbar Hedayatizadeh-Omran, Ehsan Zaboli, Mohammad Mehdi Ghaffari-Hamedani, Ghasem Janbabaei, Ghasem Ahangari

Abstract read
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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Omolbanin AmjadiDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, P.O. Box: 1497716316, Iran.ORCID http://orcid.org/0000-0002-1328-6285
Akbar Hedayatizadeh-OmranGastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.ORCID http://orcid.org/0000-0002-9219-883X
Ehsan ZaboliGastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.ORCID http://orcid.org/0000-0003-4009-717X
Mohammad Mehdi Ghaffari-HamedaniDepartment of Surgery, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.ORCID http://orcid.org/0000-0003-4667-9824
Ghasem JanbabaeiShariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-2651-6200
Ghasem AhangariDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, P.O. Box: 1497716316, Iran. ghah@nigeb.ac.ir.ORCID http://orcid.org/0000-0003-1557-4050
Mazandaran University of Medical Sciences · IRNational Institute of Genetic Engineering and Biotechnology · IRShariati Hospital · IR

Funding

Mazandaran University of Medical Sciences MAZUMS.7870National Center for Genetic Engineering and Biotechnology Grant no.772
6 · The paper itself

Abstract

backgroundGastric cancer (GC) is the fifth most common cancer worldwide and the most commonly diagnosed cancer in Iran. The nervous system provides proximity to tumor cells by releasing neurotransmitters such as dopamine and presenting them to the corresponding receptor-bearing tumors. While nerve fibers infiltrate the tumor microenvironment, little is known about the expression levels of dopamine (DA), dopamine receptors (DRs), and catechol-O-methyltransferase (COMT) in GC patients.

methodsDRs and COMT expression were analyzed in 45 peripheral blood mononuclear cells (PBMCs) and 20 paired tumor and adjacent tissue of GC patients by quantitative polymerase chain reaction. DA was measured in plasma specimens using enzyme-linked immunosorbent assay. Protein-protein interaction analysis was carried out to identify GC-related hub genes.

resultsIncreased expression of DRD1-DRD3 was found in tumor specimens compared with adjacent non-cancerous specimens (P < 0.05). A positive correlation was found between DRD1 and DRD3 expression (P = 0.009); DRD2 and DRD3 expression (P = 0.04). Plasma levels of dopamine were significantly lower in patients (1298 pg/ml) than in controls (4651 pg/ml). DRD1-DRD4 and COMT were up-regulated in PBMCs of patients compared with controls (P < 0.0001). Bioinformatic analyses showed 30 hub genes associated with Protein kinase A and extracellular signal-regulated kinase signaling pathways.

conclusionsThe findings indicated dysregulation of DRs and COMT mRNA expression in GC and suggest that the brain- gastrointestinal axis may mediate gastric cancer development. Network analysis revealed that combination treatments could be considered for optimizing and improving the precision treatment of GC.

Indexed as

DopamineStomach NeoplasmsCatechol O-MethyltransferaseHumansLeukocytes, MononuclearReceptors, DopamineTumor MicroenvironmentCatechol O-MethyltransferaseDopamineReceptors, DopamineBrain-GI axisCOMTGastric cancerHub genesNeurotransmitter receptorsProtein–protein interaction network

Identifiers

PMID37330941
OpenAlexW4381085824

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.