Evidence map›Paper›PMID 37331250›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2023

Difference in acute and chronic stage ischemic stroke metabolic markers with controls.

Evgeny V Sidorov, Madhusmita Rout, Chao Xu, Larsen Jordan, Evan Fields, Blair Apple, Kyle Smith, David Gordon, Juliane Chainakul, Dharambir K Sanghera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Corroborated evidence on change of metabolome after ischemic stroke due to large vessel occlusion.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Evgeny V SidorovDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, USA. Electronic address: evgeny-sidorov@ouhsc.edu.
Madhusmita RoutPhysiology, College of Medicine, University of Oklahoma Health Sciences Center, USA.
Chao XuBiostatistics and Epidemiology, University of Oklahoma Health Sciences Center, USA.
Larsen JordanDepartment of Neurology, Duke University, NC, USA.
Evan FieldsDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Blair AppleDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Kyle SmithDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
David GordonDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, USA.
Juliane ChainakulDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Dharambir K SangheraOklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, USA; Physiology, College of Medicine, University of Oklahoma Health Sciences Center, USA; Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, USA; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, USA; Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, USA. Electronic address: Dharambir-sanghera@ouhsc.edu.

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
Genome, Metabolome, Ancestry and Diabetes Health DisparityR01DK118427 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DUGGIRALA, RAVINDRANATH, GORING, HARALD HEINZ HERBERT · 2019 to 2023
$2.5M
NCI NIH HHS P30 CA225520NIDDK NIH HHS R01 DK118427
6 · The paper itself

Abstract

backgroundAcute Ischemic Stroke (AIS), a major cause of disability, was previously associated with multiple metabolomic changes, but many findings were contradictory. Case-control and longitudinal study designs could have played a role in that. To clarify metabolomic changes, we performed a simultaneous comparison of ischemic stroke metabolome in acute, chronic stages of stroke and controls.

methodsThrough the nuclear magnetic resonance (NMR) platform, we evaluated 271 serum metabolites from a cohort of 297 AIS patients in acute and chronic stages and 159 controls. We used Sparse Partial Least Squares-Discriminant analysis (sPLS-DA) to evaluate group disparity; multivariate regression to compare metabolome in acute, chronic stages of stroke and controls; and mixed regression to compare metabolome acute and chronic stages of stroke. We applied false discovery rate (FDR) to our calculations.

resultsThe sPLS-DA revealed separation of the metabolome in acute, chronic stages of stroke and controls. Regression analysis identified 38 altered metabolites. Ketones, branched-chain amino acids (BCAAs), energy, and inflammatory compounds were mostly elevated, while alanine and glutamine were decreased in the acute stage. These metabolites declined/increased in the chronic stage, often to the same levels as in controls. Levels of fatty acids, phosphatidylcholines, phosphoglycerides, and sphingomyelins did not change between acute and chronic stages, but were different comparing to controls.

conclusionOur pilot study identified metabolites associated with acute stage of ischemic stroke and those that are altered in stroke patients comparing to controls regardless of stroke acuity. Future investigation in a larger independent cohort is needed to validate these findings.

Indexed as

Ischemic StrokeStrokeAlanineBiomarkersHumansLongitudinal StudiesPilot ProjectsAlanineBiomarkersBiomarkers, Amino acidsKetone bodiesMetabolomicsOxidative stressStroke

Identifiers

PMID37331250
PMCPMC10527469

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.