Evidence map›Paper›PMID 37332597›Full record

ArticleiScience2023

Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa.

Lin Jin, Mahendra P Kashyap, Yunjia Chen, Jasim Khan, Yuanyuan Guo, Jari Q Chen, Madison B Lee, Zhiping Weng, Allen Oak, Prasanth Patcha and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Lin JinCenter for Epigenomics and Translational Research in Inflammatory Skin Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Mahendra P KashyapDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Yunjia ChenDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jasim KhanDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Yuanyuan GuoDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jari Q ChenHoover High School, Hoover, Birmingham, AL 35244, USA.
Madison B LeeSchool of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Zhiping WengCenter for Epigenomics and Translational Research in Inflammatory Skin Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Allen OakDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Prasanth PatchaDivision of Plastic Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Tiffany MayoDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rajesh SinhaDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Venkatram AtigaddaDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Shahid M MukhtarDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jessy S DeshaneDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chander RamanDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Carly ElstonDepartment of Dermatology and Dermatopathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Boni E ElewskiDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Craig A ElmetsDepartment of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Mohammad AtharCenter for Epigenomics and Translational Research in Inflammatory Skin Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · USHoover Institution · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
RXR Rexinoids for Cancer ChemopreventionP01CA210946 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ATHAR, MOHAMMAD · 2017 to 2021
$7.3M
Project 5 Nano-micro Hybrid Fibrous Materials for Containment Removal and Site RemediationP42ES027723 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUNGU, CLAUDIU T · 2020 to 2024
$6.7M
Development of Potent and non-toxic rexinoids to prevent non-melanoma skin cancerR01CA276683 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Venkatram Reddy Atigadda · 2023 to 2026
$2.4M
Chemoprevention of environmental UVB-induced skin cancer in immunosuppressed miceR01ES026219 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ATHAR, MOHAMMAD · 2016 to 2020
$1.7M
NCATS NIH HHS TL1 TR001880NCI NIH HHS P01 CA210946NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA276683NIEHS NIH HHS P42 ES027723NIEHS NIH HHS R01 ES026219
6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a skin disorder that causes chronic painful inflammation and hyperproliferation, often with the comorbidity of invasive keratoacanthoma (KA). Our research, employing high-resolution immunofluorescence and data science approaches together with confirmatory molecular analysis, has identified that the 5'-cap-dependent protein translation regulatory complex eIF4F is a key factor in the development of HS and is responsible for regulating follicular hyperproliferation. Specifically, eIF4F translational targets, Cyclin D1 and c-MYC, orchestrate the development of HS-associated KA. Although eIF4F and

Indexed as

BiochemistryBiological sciencesMedical biochemistry

Identifiers

PMID37332597
PMCPMC10275975
OpenAlexW4377115786

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.