Evidence map›Paper›PMID 37333052›Full record

ArticleSarcoma2023

Fibroblast Activation Protein Expression in Sarcomas.

Jacquelyn N Crane, Danielle S Graham, Christine E Mona, Scott D Nelson, Alireza Samiei, David W Dawson, Sarah M Dry, Marwan G Masri, Joseph G Crompton, Matthias R Benz and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sarcoma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Feasibility and therapeutic potential of [European journal of nuclear medicine and molecular imaging · 2024
    Trial
  2. Review
  3. Article
  4. Differential [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Review
  6. Article
  7. Combined antitumor activity of [EJNMMI research · 2026
    Article
  8. Review
  9. Article
  10. Article
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jacquelyn N CraneDepartment of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Stanford University School of Medicine, 1000 Welch Rd, Suite 300, Palo Alto, CA 94304, USA.ORCID https://orcid.org/0000-0002-8227-5694
Danielle S GrahamUniversity of California Los Angeles, Department of Surgery, Los Angeles, CA, USA.
Christine E MonaUniversity of California Los Angeles, Department of Molecular and Medical Pharmacology, Los Angeles, CA, USA.
Scott D NelsonUniversity of California Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.
Alireza SamieiUniversity of California Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.
David W DawsonUniversity of California Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.
Sarah M DryUniversity of California Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.
Marwan G MasriUniversity of California Los Angeles, Department of Molecular and Medical Pharmacology, Los Angeles, CA, USA.
Joseph G CromptonUniversity of California Los Angeles, Department of Surgery, Los Angeles, CA, USA.
Matthias R BenzUniversity of California Los Angeles, Department of Molecular and Medical Pharmacology, Los Angeles, CA, USA.
Johannes CzerninUniversity of California Los Angeles, Department of Molecular and Medical Pharmacology, Los Angeles, CA, USA.
Fritz C EilberUniversity of California Los Angeles, Department of Surgery, Los Angeles, CA, USA.
Thomas G GraeberUniversity of California Los Angeles, Department of Molecular and Medical Pharmacology, Los Angeles, CA, USA.
Jeremie CalaisUniversity of California Los Angeles, Department of Molecular and Medical Pharmacology, Los Angeles, CA, USA.
Noah C FedermanUniversity of California Los Angeles, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
University of California, Los Angeles · USStanford University · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Objectives: Fibroblast activation protein alpha (FAP) is highly expressed by cancer-associated fibroblasts in multiple epithelial cancers. The aim of this study was to characterize FAP expression in sarcomas to explore its potential utility as a diagnostic and therapeutic target and prognostic biomarker in sarcomas. Methods: Available tissue samples from patients with bone or soft tissue tumors were identified at the University of California, Los Angeles. FAP expression was evaluated via immunohistochemistry (IHC) in tumor samples ( Results: The majority of tumor samples had FAP IHC intensity scores ≥2 and density scores ≥25% for stromal cells (77.7%) and tumor cells (50.7%). All desmoid fibromatosis, myxofibrosarcoma, solitary fibrous tumor, and undifferentiated pleomorphic sarcoma samples had medium or high FAP overall scores. Sarcomas were among cancer types with the highest mean FAP expression by RNA sequencing. There was no significant difference in OS in patients with sarcoma with low versus high FAP expression. Conclusion: The majority of the sarcoma samples showed FAP expression by both stromal and tumor/nonstromal cells. Further investigation of FAP as a potential diagnostic and therapeutic target in sarcomas is warranted.

Identifiers

PMID37333052
PMCPMC10275689
OpenAlexW4380090552

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.