Evidence map›Paper›PMID 37333317›Full record

ArticlebioRxiv : the preprint server for biology2023

Novel Roles for Diacylglycerol in Synaptic Vesicle Priming and Release Revealed by Complete Reconstitution of Core Protein Machinery.

R Venkat Kalyana Sundaram, Atrouli Chatterjee, Manindra Bera, Kirill Grushin, Aniruddha Panda, Feng Li, Jeff Coleman, Seong Lee, Sathish Ramakrishnan, Andreas M Ernst and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

R Venkat Kalyana SundaramNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Atrouli ChatterjeeNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Manindra BeraNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Kirill GrushinNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Aniruddha PandaNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Feng LiNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Jeff ColemanNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Seong LeeNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Sathish RamakrishnanNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Andreas M ErnstSchool of Biological Sciences, University of California San Diego, La Jolla CA 92093, USA.
Kallol GuptaNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
James E RothmanNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Shyam S KrishnakumarNanobiology Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Yale University · USUniversity of California San Diego · US

Funding

Regulation of Membrane Fusion in ExocytosisR01DK027044 · NIDDK · YALE UNIVERSITY · PI KRISHNAKUMAR, SHYAM S · 1986 to 2021
$8.2M
MECHANISMS OF INTRACELLULAR MEMBRANE FUSIONR37DK027044 · NIDDK · YALE UNIVERSITY · PI ROTHMAN, JAMES · 1992 to 2012
$5.3M
Laying the Groundwork for Web-based Elemental Imaging Software: The MicroAnalysis ToolkitR24GM141194 · NIGMS · DARTMOUTH COLLEGE · PI Brian P Jackson · 2021 to 2026
$3.1M
NIDDK NIH HHS R01 DK027044NIDDK NIH HHS R37 DK027044NIGMS NIH HHS R24 GM141194
6 · The paper itself

Abstract

Here we introduce the full functional reconstitution of genetically-validated core protein machinery (SNAREs, Munc13, Munc18, Synaptotagmin, Complexin) for synaptic vesicle priming and release in a geometry that enables detailed characterization of the fate of docked vesicles both before and after release is triggered with Ca SIGNIFICANCE STATEMENT: Munc13 and Munc18 are SNARE-associated chaperones that act as "priming" factors, facilitating the formation of a pool of docked, release-ready vesicles and regulating Ca

Identifiers

PMID37333317
PMCPMC10274626
OpenAlexW4379617781

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.