Evidence map›Paper›PMID 37334004›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2023

Exploring personalized structural connectomics for moderate to severe traumatic brain injury.

Phoebe Imms, Adam Clemente, Evelyn Deutscher, Ahmed M Radwan, Hamed Akhlaghi, Paul Beech, Peter H Wilson, Andrei Irimia, Govinda Poudel, Juan F Domínguez Duque and 1 more

Open access · goldAbstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Phoebe ImmsLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-7205-4177
Adam ClementeHealthy Brain and Mind Research Centre, School of Behavioural, Health, and Human Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.ORCID https://orcid.org/0000-0002-4742-7015
Evelyn DeutscherCognitive Neuroscience Unit, School of Psychology, Faculty of Health, Deakin University, Burwood, Victoria, Australia.ORCID https://orcid.org/0000-0002-6846-4456
Ahmed M RadwanKU Leuven, Department of Imaging and Pathology, Translational MRI, Leuven, Belgium.ORCID https://orcid.org/0000-0002-4819-548X
Hamed AkhlaghiEmergency Department, St. Vincent's Hospital (Melbourne), Faculty of Health, Deakin University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-3929-7265
Paul BeechDepartment of Radiology and Nuclear Medicine, The Alfred Hospital, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0003-3871-3682
Peter H WilsonHealthy Brain and Mind Research Centre, School of Behavioural, Health, and Human Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.ORCID https://orcid.org/0000-0003-3747-0287
Andrei IrimiaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9254-9388
Govinda PoudelMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-0043-7531
Juan F Domínguez DuqueCognitive Neuroscience Unit, School of Psychology, Faculty of Health, Deakin University, Burwood, Victoria, Australia.ORCID https://orcid.org/0000-0002-6715-1060
Karen CaeyenberghsCognitive Neuroscience Unit, School of Psychology, Faculty of Health, Deakin University, Burwood, Victoria, Australia.ORCID https://orcid.org/0000-0001-7009-6843
Deakin University · AUAustralian Catholic University · AUUniversity of Southern California · USKU Leuven · BEThe Alfred Hospital · AU

Funding

Effects of blood-brain barrier disruption upon white matter connectivity subsequent to traumatic brain injuryR01NS100973 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI IRIMIA, ANDREI · 2017 to 2021
$1.6M
NINDS NIH HHS R01 NS100973
6 · The paper itself

Abstract

Graph theoretical analysis of the structural connectome has been employed successfully to characterize brain network alterations in patients with traumatic brain injury (TBI). However, heterogeneity in neuropathology is a well-known issue in the TBI population, such that group comparisons of patients against controls are confounded by within-group variability. Recently, novel single-subject profiling approaches have been developed to capture inter-patient heterogeneity. We present a personalized connectomics approach that examines structural brain alterations in five chronic patients with moderate to severe TBI who underwent anatomical and diffusion magnetic resonance imaging. We generated individualized profiles of lesion characteristics and network measures (including personalized graph metric GraphMe plots, and nodal and edge-based brain network alterations) and compared them against healthy reference cases (

Indexed as

Graph theoryLesion fillingPersonalized connectomicsPersonalized medicineStructural connectomicsTraumatic brain injury

Identifiers

PMID37334004
PMCPMC10270710
OpenAlexW4296379025

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.