Evidence map›Paper›PMID 37334869›Full record

ArticleBirth defects research2023

Gadolinium during human pregnancy following administration of gadolinium chelate before pregnancy.

Rachel M Coyte, Thomas Darrah, John Olesik, Emily Barrett, Thomas G O'Connor, Jessica Brunner, Tanzy Love, Rogelio Perez-D'Gregorio, Henry Z Wang, Lauren M Aleksunes and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Gadolinium Intermediate Elimination and Persistent Symptoms After Magnetic Resonance Imaging Contrast Agent Exposure.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Rachel M CoyteSchool of Earth Sciences, The Ohio State University, Columbus, Ohio, USA.
Thomas DarrahSchool of Earth Sciences, The Ohio State University, Columbus, Ohio, USA.
John OlesikSchool of Earth Sciences, The Ohio State University, Columbus, Ohio, USA.
Emily BarrettDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Thomas G O'ConnorDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Jessica BrunnerDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Tanzy LoveDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
Rogelio Perez-D'GregorioDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Henry Z WangDepartment of Imaging Science, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Lauren M AleksunesDepartment of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey, USA.
Brian BuckleyEnvironmental and Occupational Health Sciences Institute, Piscataway, New Jersey, USA.
Cathleen DohertyEnvironmental and Occupational Health Sciences Institute, Piscataway, New Jersey, USA.
Richard K MillerDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.ORCID 0000-0002-6691-7538
University of Rochester · USThe Ohio State University · USEnvironmental and Occupational Health Sciences Institute · USRutgers, The State University of New Jersey · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Pre- and Postnatal Exposure Periods for Child Health: Common Risks and Shared MechanismsUH3OD023349 · OD · UNIVERSITY OF ROCHESTER · PI Emily S Barrett, Richard Kermit Miller · 2018 to 2026
$15.9M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
Understanding Prenatal Signals and Infant Development (UPSIDE)R01HD083369 · NICHD · UNIVERSITY OF ROCHESTER · PI BARRETT, EMILY S · 2015 to 2019
$2.6M
NICHD NIH HHS R01 HD083369NIEHS NIH HHS P30 ES001247NIH HHS UG3 OD023271NIH HHS UH3 OD023271NIH HHS UH3 OD023349
6 · The paper itself

Abstract

Gadolinium (Gd), a toxic rare earth element, has been shown to dissociate from chelating agents and bioaccumulate within tissues, raising concerns about the possibility of their remobilization during pregnancy with subsequent free Gd exposures to developing fetuses. Gd chelates are among the most commonly used magnetic resonance imaging (MRI) contrast agents. This investigation was undertaken after the detection of elevated Gd (800-1000× higher than the usual rare earth element levels) in preliminary unpublished studies from the placentae of subjects in the NIH ECHO/UPSIDE Rochester Cohort Study and unpublished studies from placentae analyzed in formalin-fixed placental specimens from Surgical Pathology at the University of Rochester. Fifteen pregnancies with elevated Gd were studied (12 first pregnancies and 3 second pregnancies). Maternal bloods were collected from all three trimesters, maternal, and cord (fetal) bloods at delivery as well as placental tissue. Breastmilk was also collected from selected mothers. It was determined that Gd was present in maternal bloods from all three trimesters, and in cord bloods and breastmilk in both first and second pregnancies. These results emphasize the need to fully appreciate the implications of pre-pregnancy exposure to Gd chelates and its potential effects on maternal and fetal health.

Indexed as

Contrast MediaGadoliniumChelating AgentsCohort StudiesFemaleGravidityHumansMothersPlacentaPregnancyChelating AgentsContrast MediaGadoliniumbreastmilkgadoliniumhumanmaternal and cord bloodspharmacokineticsplacentapregnancy

Identifiers

PMID37334869
PMCPMC11784526
OpenAlexW4381192450

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.