Evidence mapPaperPMID 37336641Full record

ReviewObesity reviews : an official journal of the International Association for the Study of Obesity2023

The damaging duo: Obesity and excess dietary salt contribute to hypertension and cardiovascular disease.

Joseph C Watso, Ibra S Fancher, Dulce H Gomez, Zachary J Hutchison, Orlando M Gutiérrez, Austin T Robinson

Open access · greenAbstract readReview
In one paragraph

Review in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Can We Protect Our Hearts by Sweating Out Excess Sodium?Exercise and sport sciences reviews · 2026
    Review
  3. Observational
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Joseph C WatsoDepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida, USA.ORCID 0000-0001-7840-0643
Ibra S FancherDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.ORCID 0000-0003-4677-6755
Dulce H GomezSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.ORCID 0000-0003-3245-7083
Zachary J HutchisonSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.ORCID 0000-0001-9091-5973
Orlando M GutiérrezDivision of Nephrology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-6593-3571
Austin T RobinsonSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.ORCID 0000-0001-8250-3952
Auburn University · USBrigham and Women's Hospital · USFlorida State University · USUniversity of Alabama at Birmingham · USUniversity of Delaware · US

Funding

Investigator Development CoreP50MD017338 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$5.9M
Quantifying the Influence of Pathological Hemodynamics on Cerebral Microvascular Dysfunction and Neuronal InjuryP20GM113125 · UNIVERSITY OF DELAWARE · 2025 to 2025
$2.3M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1987 to 2005
$660k
Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with ObesityK01HL160772 · FLORIDA STATE UNIVERSITY · 2025 to 2025
$138k
PRedOctoral PhD and MD research training in TEams (PROmoTE)R25DK112731 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$107k
NCATS NIH HHS UL1 TR003096NHLBI NIH HHS K01 HL147998NHLBI NIH HHS K01 HL160772NHLBI NIH HHS R01 HL144716NHLBI NIH HHS R15 HL165325NIDDK NIH HHS K24 DK116180NIDDK NIH HHS R01 DK128803NIDDK NIH HHS R25 DK112731NIDDK NIH HHS T32 DK007545NIGMS NIH HHS P20 GM113125NIMHD NIH HHS P50 MD017338
6 · The paper itself

Abstract

Hypertension is a primary risk factor for cardiovascular disease. Cardiovascular disease is the leading cause of death among adults worldwide. In this review, we focus on two of the most critical public health challenges that contribute to hypertension-obesity and excess dietary sodium from salt (i.e., sodium chloride). While the independent effects of these factors have been studied extensively, the interplay of obesity and excess salt overconsumption is not well understood. Here, we discuss both the independent and combined effects of excess obesity and dietary salt given their contributions to vascular dysfunction, autonomic cardiovascular dysregulation, kidney dysfunction, and insulin resistance. We discuss the role of ultra-processed foods-accounting for nearly 60% of energy intake in America-as a major contributor to both obesity and salt overconsumption. We highlight the influence of obesity on elevated blood pressure in the presence of a high-salt diet (i.e., salt sensitivity). Throughout the review, we highlight critical gaps in knowledge that should be filled to inform us of the prevention, management, treatment, and mitigation strategies for addressing these public health challenges.

Indexed as

Cardiovascular DiseasesHypertensionAdultBlood PressureDietHumansObesitySodium Chloride, DietarySodium Chloride, Dietaryblood pressuredietary sodiumhypertensionobesity

Identifiers

PMID37336641
PMCPMC10406397
OpenAlexW4381162775

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.