ArticleGenome biology2023
Characterization of novel loci controlling seed oil content in Brassica napus by marker metabolite-based multi-omics analysis.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 46 citations in OpenAlex.
- Advanced breeding techniques inPlant signaling & behavior · 2026Review
- Old drug with new application: spironolactone suppresses Panx 1-mediated CaInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Development of molecular markers associated with saline-alkali tolerance in rapeseed (Brassica napus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Roles of Metabolites Unveiled by Metabolomics inMetabolites · 2026Review
- BnaC03.SEIPIN1 improves seed oil content by increasing the number of lipid droplets in Brassica napus.BMC plant biology · 2026Article
- Dissecting the genetic architecture of seed-related traits in Brassica napus by integrating multi-omics analysis and VIS-NIR hyperspectral imaging.Genome biology · 2026Article
- Exploring metabolite diversity in global rapeseed germplasm: insights into ecotypes, geographical influences, and correlations with diabetes.BMC plant biology · 2025Article
- Unraveling the genetic mechanisms of waterlogging stress through the leaf metabolome of a sweet corn panel.BMC plant biology · 2025Article
- Marker Metabolite-Based Multi-Omics Analysis Identifies New Loci Controlling Thousand Seed Weight in Brassica Napus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ningza 182: A rapeseed variety with a moderately compact plant type, bred for high yield and high oil content.Molecular breeding : new strategies in plant improvement · 2025Article
- A panoramic view of cotton resistance toiMeta · 2025Article
- The Alpha/Beta-Hydrolase Fold Superfamily inInternational journal of molecular sciences · 2025Article
- Integrative omics analysis reveals the genetic basis of fatty acid composition in Brassica napus seeds.Genome biology · 2025Article
- Untargeted Metabolomics Analysis Reveals Differential Accumulation of Flavonoids Between Yellow-Seeded and Black-Seeded Rapeseed Varieties.Plants (Basel, Switzerland) · 2025Article
- A rare dominant alleleScience advances · 2025Article
- Unveiling unique metabolomic and transcriptomic profiles in three Brassicaceae crops.Frontiers in plant science · 2025Article
- PCMD: A multilevel comparison database of intra- and cross-species metabolic profiling in 530 plant species.Plant communications · 2024Article
- Article
- Integrating QTL mapping and transcriptomics to decipher the genetic architecture of sterol metabolism inHorticulture research · 2024Article
- Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages.Scientific reports · 2024Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeed oil content is an important agronomic trait of Brassica napus (B. napus), and metabolites are considered as the bridge between genotype and phenotype for physical traits.
resultsUsing a widely targeted metabolomics analysis in a natural population of 388 B. napus inbred lines, we quantify 2172 metabolites in mature seeds by liquid chromatography mass spectrometry, in which 131 marker metabolites are identified to be correlated with seed oil content. These metabolites are then selected for further metabolite genome-wide association study and metabolite transcriptome-wide association study. Combined with weighted correlation network analysis, we construct a triple relationship network, which includes 21,000 edges and 4384 nodes among metabolites, metabolite quantitative trait loci, genes, and co-expression modules. We validate the function of BnaA03.TT4, BnaC02.TT4, and BnaC05.UK, three candidate genes predicted by multi-omics analysis, which show significant impacts on seed oil content through regulating flavonoid metabolism in B. napus.
conclusionsThis study demonstrates the advantage of utilizing marker metabolites integrated with multi-omics analysis to dissect the genetic basis of agronomic traits in crops.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.