Evidence map›Paper›PMID 37337295›Full record

ArticleTrials2023

Effect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage-study protocol for a randomized clinical trial.

Mikael Laaksonen, Jaakko Rinne, Melissa Rahi, Jussi P Posti, Ruut Laitio, Juri Kivelev, Ilkka Saarenpää, Dan Laukka, Juhana Frösen, Antti Ronkainen and 18 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04696523 (Effect of Xenon on Brain Injury, Neurological Outcome and Survival in Patients After Aneurysmal Subarachnoid Hemorrhage), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04696523 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Xenon on Brain Injury, Neurological Outcome and Survival in Patients After Aneurysmal Subarachnoid Hemorrhage

TypeinterventionalSponsorTurku University HospitalRan2025 to 2029Enrolled160ConditionsSubarachnoid Hemorrhage, Aneurysmal, Cerebral Injury, Cerebral Ischemia, Cerebral InfarctionArmsXenon, air/oxygen
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 5 institutions in 1 country.

Mikael LaaksonenDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, P.O. Box 52, FIN-20521, Turku, Finland. mikael.laaksonen@tyks.fi.ORCID http://orcid.org/0009-0003-1879-0418
Jaakko RinneNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Melissa RahiNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Jussi P PostiNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Ruut LaitioDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, P.O. Box 52, FIN-20521, Turku, Finland.
Juri KivelevNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Ilkka SaarenpääNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Dan LaukkaNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.
Juhana FrösenDepartment of Neurosurgery, Faculty of Medicine and Health Technology, Tampere University Hospital, University of Tampere, Tampere, Finland.
Antti RonkainenDepartment of Neurosurgery, Faculty of Medicine and Health Technology, Tampere University Hospital, University of Tampere, Tampere, Finland.
Stepani BendelDepartment of Intensive Care, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.
Jaakko LångsjöDepartment of Anesthesiology and Intensive Care, Tampere University Hospital and University of Tampere, Tampere, Finland.
Marika Ala-PeijariDepartment of Anesthesiology and Intensive Care, Tampere University Hospital and University of Tampere, Tampere, Finland.
Jani SaunavaaraDepartment of Medical Physics, Turku University Hospital and University of Turku, Turku, Finland.
Riitta ParkkolaDepartment of Radiology, Turku University Hospital and University of Turku, Turku, Finland.
Mikko NymanDepartment of Radiology, Turku University Hospital and University of Turku, Turku, Finland.
Ilkka K MartikainenDepartment of Radiology, Tampere University Hospital and University of Tampere, Tampere, Finland.
Alex M DickensAnalysis of the metabolomics, University of Turku, Turku BioscienceTurku, Finland.
Juha RinneTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
Mika ValtonenDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, P.O. Box 52, FIN-20521, Turku, Finland.
Teijo I SaariDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, P.O. Box 52, FIN-20521, Turku, Finland.
Timo KoivistoDepartment of Neurosurgery, Kuopio University Hospital, University of Eastern Finland, NeurocenterKuopio, Finland.
Paula BendelDepartment of Radiology, Kuopio University Hospital, Kuopio, Finland.
Timo RoineDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
Antti SarasteHeart Centre, Turku University Hospital, Turku University Hospital and University of Turku, Turku, Finland.
Tero VahlbergDepartment of Biostatistics, University of Turku, Turku, Finland.
Juha TanttariTechnical Analysis, Elomatic Consulting & Engineering, Thane, India.
Timo LaitioDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, P.O. Box 52, FIN-20521, Turku, Finland.
University of Turku · FITampere University Hospital · FIUniversity of Eastern Finland · FIAalto University · FIKuopio University Hospital · FI

Funding

Biotieteiden ja Ympäristön Tutkimuksen Toimikunta 333010
6 · The paper itself

Abstract

backgroundAneurysmal subarachnoid hemorrhage (aSAH) is a neurological emergency, affecting a younger population than individuals experiencing an ischemic stroke; aSAH is associated with a high risk of mortality and permanent disability. The noble gas xenon has been shown to possess neuroprotective properties as demonstrated in numerous preclinical animal studies. In addition, a recent study demonstrated that xenon could attenuate a white matter injury after out-of-hospital cardiac arrest.

methodsThe study is a prospective, multicenter phase II clinical drug trial. The study design is a single-blind, prospective superiority randomized two-armed parallel follow-up study. The primary objective of the study is to explore the potential neuroprotective effects of inhaled xenon, when administered within 6 h after the onset of symptoms of aSAH. The primary endpoint is the extent of the global white matter injury assessed with magnetic resonance diffusion tensor imaging of the brain. DISCUSSION: Despite improvements in medical technology and advancements in medical science, aSAH mortality and disability rates have remained nearly unchanged for the past 10 years. Therefore, new neuroprotective strategies to attenuate the early and delayed brain injuries after aSAH are needed to reduce morbidity and mortality.

trial registrationClinicalTrials.gov NCT04696523. Registered on 6 January 2021. EudraCT, EudraCT Number: 2019-001542-17. Registered on 8 July 2020.

Indexed as

Brain InjuriesSubarachnoid HemorrhageDiffusion Tensor ImagingEquivalence Trials as TopicFollow-Up StudiesHumansMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicSingle-Blind MethodXenonXenonAneurysmal subarachnoid hemorrhageaSAHNeuroprotectionRandomized controlled trialXenon

Identifiers

PMID37337295
PMCPMC10280919
OpenAlexW4381249026

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.