Evidence map›Paper›PMID 37338252›Full record

ArticleDevelopmental psychobiology2023

Effects of anesthesia exposure on postnatal maturation of white matter in rhesus monkeys.

Chalmer Tomlinson, Roza Vlasova, Khalid Al-Ali, Jeffrey T Young, Yundi Shi, Gabriele R Lubach, Andrew L Alexander, Christopher L Coe, Martin Styner, Jason Fine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental psychobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chalmer TomlinsonDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Roza VlasovaDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-6455-8949
Khalid Al-AliDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jeffrey T YoungDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Yundi ShiDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Gabriele R LubachHarlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Andrew L AlexanderWaisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Christopher L CoeHarlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Martin StynerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jason FineDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIVEN, JOSEPH · 1985 to 2012
$28.7M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 1985 to 2015
$25.2M
Summer Research ExperienceP50MH100031 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2013 to 2017
$10.4M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2013 to 2019
$8.0M
Developmental Brain Atlas Tools and Data Applied to Humans and MacaquesR01MH091645 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NIETHAMMER, MARC, STYNER, MARTIN ANDREAS · 2010 to 2014
$2.1M
Biostatistics and Mental Health Neuroimaging and Genomics Training GrantT32MH106440 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE, KOSOROK, MICHAEL R · 2015 to 2019
$970k
NICHD NIH HHS P30 HD003110NICHD NIH HHS P30 HD003352NICHD NIH HHS U54 HD079124NIMH NIH HHS P50 MH100031NIMH NIH HHS R01 MH091645NIMH NIH HHS T32 MH106440
6 · The paper itself

Abstract

There is increasing concern about the potential effects of anesthesia exposure on the developing brain. The effects of relatively brief anesthesia exposures used repeatedly to acquire serial magnetic resonance imaging scans could be examined prospectively in rhesus macaques. We analyzed magnetic resonance diffusion tensor imaging (DTI) of 32 rhesus macaques (14 females, 18 males) aged 2 weeks to 36 months to assess postnatal white matter (WM) maturation. We investigated the longitudinal relationships between each DTI property and anesthesia exposure, taking age, sex, and weight of the monkeys into consideration. Quantification of anesthesia exposure was normalized to account for variation in exposures. Segmented linear regression with two knots provided the best model for quantifying WM DTI properties across brain development as well as the summative effect of anesthesia exposure. The resulting model revealed statistically significant age and anesthesia effects in most WM tracts. Our analysis indicated there were major effects on WM associated with low levels of anesthesia even when repeated as few as three times. Fractional anisotropy values were reduced across several WM tracts in the brain, indicating that anesthesia exposure may delay WM maturation, and highlight the potential clinical concerns with even a few exposures in young children.

Indexed as

AnesthesiaWhite MatterAnimalsBrainDiffusion Tensor ImagingFemaleMacaca mulattaMaleanesthesia exposuredevelopmentdiffusion tensor imaging (DTI)isofluraneketamine

Identifiers

PMID37338252
PMCPMC11000522

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.