Evidence map›Paper›PMID 37338411›Full record

ArticleJournal of virology2023

Short-Chain Fatty Acids Alleviate Vancomycin-Caused Humoral Immunity Attenuation in Rabies-Vaccinated Mice by Promoting the Generation of Plasma Cells via Akt-mTOR Pathway.

Qiong Wu, Yachun Zhang, Caiqian Wang, Yarong Hou, Wenna He, Lingli Wang, Jingyi Xiong, Zeheng Ren, Haoran Wang, Baokun Sui and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Qiong WuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yachun ZhangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Caiqian WangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yarong HouNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Wenna HeNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Lingli WangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Jingyi XiongNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Zeheng RenNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Haoran WangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Baokun SuiNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Danna ZhouKey Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Wuhan, China.
Ming ZhouNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Zhen F FuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Ling ZhaoNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-0569-8105
Huazhong Agricultural University · CNAnimal Science Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mounting evidence suggests that gut microbial composition and its metabolites, including short-chain fatty acids (SCFAs), have beneficial effects in regulating host immunogenicity to vaccines. However, it remains unknown whether and how SCFAs improve the immunogenicity of the rabies vaccine. In this study, we investigated the effect of SCFAs on the immune response to rabies vaccine in vancomycin (Vanco)-treated mice and found that oral gavage with butyrate-producing bacteria (

Indexed as

RabiesRabies VaccinesAnimalsAntibodies, ViralButyratesFatty Acids, VolatileImmunity, HumoralMicePlasma CellsProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesVancomycinAntibodies, ViralButyratesFatty Acids, VolatileProto-Oncogene Proteins c-aktRabies VaccinesTOR Serine-Threonine KinasesVancomycinAkt-mTOR pathwayB cellsgut microbiomerabies vaccineSCFAvancomycin

Identifiers

PMID37338411
PMCPMC10373539
OpenAlexW4381248351

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.