Evidence map›Paper›PMID 37339208›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy.

Maxwell B Watkins, Haoyue Wang, Audrey Burnim, Nozomi Ando

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Biophysical journal · 2026
    Article
  3. Article
  4. Cobalt complexes in biology and medicine: enzymatic functions, pharmacological applications, and health challenges.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Introduction to the SAMPREP special issue.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  9. An unusual Co-S bond links BProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Laboratory evolution ofJournal of bacteriology · 2025
    Article
  11. Article
  12. Article
  13. Emerging Roles of Vitamin BInternational journal of molecular sciences · 2024
    Review
  14. Article
  15. Cobalt-Sulfur Coordination Chemistry Drives BJournal of the American Chemical Society · 2023
    Article
  16. Article
  17. The structural basis of protein conformational switching revealed by experimental and AlphaFold2 analyses.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Maxwell B WatkinsDepartment of Chemistry, Princeton University, Princeton, NJ 08544.ORCID 0000-0003-4559-2049
Haoyue WangField of Biophysics, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2933-0030
Audrey BurnimDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-9962-1397
Nozomi AndoDepartment of Chemistry, Princeton University, Princeton, NJ 08544.ORCID 0000-0001-7062-1644
Cornell University · USPrinceton University · US

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Protein Allostery and Catalysis Beyond Bragg DiffractionR35GM124847 · NIGMS · PRINCETON UNIVERSITY · PI Nozomi Ando · 2017 to 2026
$4.1M
Structural Characterizations of Transient and Heterogeneous Protein ComplexesR00GM100008 · NIGMS · PRINCETON UNIVERSITY · PI ANDO, NOZOMI · 2014 to 2016
$747k
Lab Source for Small/Wide Angle X-ray Scattering ExperimentsS10OD028617 · OD · CORNELL UNIVERSITY · PI POLLACK, LOIS · 2020 to 2020
$549k
Structural Characterizations of Transient and Heterogeneous Protein ComplexesK99GM100008 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANDO, NOZOMI · 2012 to 2013
$176k
NIGMS NIH HHS K99 GM100008NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R00 GM100008NIGMS NIH HHS R35 GM124847NIGMS NIH HHS U24 GM129539NIH HHS S10 OD028617
6 · The paper itself

Abstract

Cobalamin-dependent methionine synthase (MetH) catalyzes the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate (CH

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseEscherichia coliCryoelectron MicroscopyFolic AcidMethionineScattering, Small AngleVitamin B 12X-Ray DiffractionX-Rays5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseFolic AcidMethionineVitamin B 12cryo-EMEnzyme dynamicsone-carbon metabolismSAXSstructure prediction

Identifiers

PMID37339208
PMCPMC10293825
OpenAlexW4381327660

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.