Evidence map›Paper›PMID 37339214›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies.

Philippe Jean, Fabienne Wong Jun Tai, Amrit Singh-Estivalet, Andrea Lelli, Cyril Scandola, Sébastien Megharba, Sandrine Schmutz, Solène Roux, Sabrina Mechaussier, Muriel Sudres and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Philippe JeanInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France.
Fabienne Wong Jun TaiInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.ORCID 0000-0002-2316-9947
Amrit Singh-EstivaletInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.ORCID 0000-0001-9932-6438
Andrea LelliInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.ORCID 0000-0002-8391-5411
Cyril ScandolaInstitut Pasteur, Université Paris Cité, Ultrastructural BioImaging, F-75015 Paris, France.
Sébastien MegharbaInstitut Pasteur, Université Paris Cité, Cytometry and Biomarkers, F-75015 Paris, France.
Sandrine SchmutzInstitut Pasteur, Université Paris Cité, Cytometry and Biomarkers, F-75015 Paris, France.
Solène RouxInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.
Sabrina MechaussierInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France.
Muriel SudresInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.
Enguerran MoulyInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.
Anne-Valérie HeritierInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.
Crystel BonnetInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.ORCID 0000-0002-1916-9119
Adeline MalletInstitut Pasteur, Université Paris Cité, Ultrastructural BioImaging, F-75015 Paris, France.ORCID 0000-0003-1604-7308
Sophie NovaultInstitut Pasteur, Université Paris Cité, Cytometry and Biomarkers, F-75015 Paris, France.
Valentina LibriInstitut Pasteur, Université Paris Cité, Cytometry and Biomarkers, F-75015 Paris, France.
Christine PetitInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France.ORCID 0000-0002-9069-002X
Nicolas MichalskiInstitut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France.ORCID 0000-0002-1287-2709
Inserm · FRInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional molecular characterization of the cochlea has mainly been driven by the deciphering of the genetic architecture of sensorineural deafness. As a result, the search for curative treatments, which are sorely lacking in the hearing field, has become a potentially achievable objective, particularly

Indexed as

DeafnessTranscriptomeAnimalsBasilar MembraneCochleaHearingMicecochleagene therapyhearingtonotopytranscriptomics

Identifiers

PMID37339214
PMCPMC10293812
OpenAlexW4381327527

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.